Endoscopic retrograde cholangiopancreatography
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|Endoscopic retrograde cholangiopancreatography|
Endoscopic retrograde cholangiopancreatography (ERCP) is a technique that combines the use of endoscopy and fluoroscopy to diagnose and treat certain problems of the biliary or pancreatic ductal systems. Through the endoscope, the physician can see the inside of the stomach and duodenum, and inject a contrast medium into the ducts in the biliary tree and pancreas so they can be seen on radiographs.
ERCP is used primarily to diagnose and treat conditions of the bile ducts and main pancreatic duct, including gallstones, inflammatory strictures (scars), leaks (from trauma and surgery), and cancer. ERCP can be performed for diagnostic and therapeutic reasons, although the development of safer and relatively non-invasive investigations such as magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasound has meant that ERCP is now rarely performed without therapeutic intent.
The following represent indications for ERCP, particularly if or when less invasive options are not adequate or definitive:
- Obstructive jaundice – This may be due to several causes
- Chronic pancreatitis is currently a controversial indication due to widespread availability of safer diagnostic modalities including endoscopic ultrasound, CT, and MRI/MRCP
- Pancreatic tumors no longer represent a valid diagnostic indication for ERCP unless they cause bile duct obstruction and jaundice. Endoscopic ultrasound represents a safer and more accurate diagnostic alternative
ERCP may be indicated in the above diagnostic scenarios when any of the following are needed:
- Endoscopic sphincterotomy (of the biliary or the pancreatic duct sphincter)
- Removal of stones or other biliary debris
- Insertion of bile duct stent(s)
- Dilation of strictures (e.g. primary sclerosing cholangitis, anastomotic strictures after liver transplantation)
- Hypersensitivity to iodinated contrast medium
- History of iodinated contrast dye anaphylaxis (although iodine-free contrast is now available)
- Acute pancreatitis (unless persistently elevated or rising bilirubin suggests ongoing obstruction)
- (Irreversible) coagulation disorder if sphincterotomy planned
- Recent myocardial infarction or pulmonary embolism
- Severe cardiopulmonary disease or other serious morbidity
The patient is sedated or anaesthetized. Then a flexible camera (endoscope) is inserted through the mouth, down the esophagus, into the stomach, through the pylorus into the duodenum where the ampulla of Vater (the union of the common bile duct and pancreatic duct) exists. The sphincter of Oddi is a muscular valve that controls the opening to the ampulla. The region can be directly visualized with the endoscopic camera while various procedures are performed. A plastic catheter or cannula is inserted through the ampulla, and radiocontrast is injected into the bile ducts and/or pancreatic duct. Fluoroscopy is used to look for blockages, or other lesions such as stones.
When needed, the opening to the ampulla can be enlarged by a cut (sphincterotomy) with an electrified wire called a sphincterotome and access into the bile duct obtained so that gallstones may be removed or other therapy performed.
Other procedures associated with ERCP include the trawling of the common bile duct with a basket or balloon to remove gallstones and the insertion of a plastic stent to assist the drainage of bile. Also, the pancreatic duct can be cannulated and stents be inserted. The pancreatic duct requires visualisation in cases of pancreatitis.
In specific cases, other specialized or ancillary endoscopes may be used for ERCP. These include mother-daughter and SpyGlass cholangioscopes (to help in diagnosis by directly visualizing the duct as opposed to only obtaining X-ray images) as well as balloon enteroscopes (e.g. in patients with post-Whipple or Roux-en-Y surgical anatomy).
The major risk of an ERCP is the development of pancreatitis, which can occur in up to 5% of all procedures. This may be self limited and mild, but may require hospitalization, and rarely has the potential to become life-threatening. Those at additional risk for pancreatitis are younger patients, females, patients with previous post-ERCP pancreatitis, procedures that involve cannulation or injection of the pancreatic duct, and patients with sphincter of Oddi dysfunction.
Intestinal perforation is a risk of any gastroenterologic endoscopic procedure, and is an additional risk if a sphincterotomy is performed. As the second part of the duodenum is anatomically in a retroperitoneal location (that is, behind the peritoneal structures of the abdomen), perforations due to sphincterotomies are retroperitoneal. Sphincterotomy is also associated with a risk of bleeding.
There is also a risk associated with the contrast dye in patients who are allergic to compounds containing iodine. Oversedation can result in dangerously low blood pressure, respiratory depression, nausea, and vomiting. Other complications (less than 1%) may include heart and lung problems, infection in the bile duct called cholangitis. Using antibiotics before the procedure shows some benefits to prevent cholangitis and septicaemia. In rare cases, ERCP can cause fatal complications.
Cases of hospital acquired infections with carbapenem resistant enterobacteriaceae linked to incompletely disinfected duodenoscopes have occurred in the U.S. since at least 2009 per the FDA. Outbreaks were reported from Virginia Mason Hospital in Seattle in 2013, UCLA Health System Los Angeles in 2015, Chicago and Pittsburgh. The FDA issued a safety communication "Design of ERCP Duodenoscopes May Impede Effective Cleaning" in February 2015, which was updated in December 2015.
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- Azeem N, Tabibian JH, Baron TH, Orhurhu V, Rosen CB, Petersen BT, Gostout CJ, Topazian MD, Levy MJ. Use of a single-balloon enteroscope compared with variable-stiffness colonoscopes for endoscopic retrograde cholangiography in liver transplant patients with Roux-en-Y biliary anastomosis. Gastrointest Endosc. 2013 Apr;77(4):568-77.
- Andriulli A, Loperfido S, Napolitano G, Niro G, Valvano MR, Spirito F, Pilotto A, Forlano R (2007). "Incidence rates of post-ERCP complications: a systematic survey of prospective studies". Am. J. Gastroenterol. 102 (8): 1781–8. doi:10.1111/j.1572-0241.2007.01279.x. PMID 17509029.
- Brand, M; Bizos, D; O'Farrell P, Jr (6 October 2010). "Antibiotic prophylaxis for patients undergoing elective endoscopic retrograde cholangiopancreatography". The Cochrane Database of Systematic Reviews (10): CD007345. doi:10.1002/14651858.CD007345.pub2. PMID 20927758.
- Cotton, Peter B. (2013-05-31). "ERCP (Endoscopic Retrograde Cholangio-Pancreatography)". Medical University of South Carolina (MUSC) Digestive Disease Center. Retrieved 2013-06-09.
- Sharon Begley; Toni Clarke (20 February 2015). "FDA knew devices spread fatal 'superbug' but does not order fix". Reuters. Retrieved 20 February 2015.
- "Deadly superbug infected patients at Seattle hospital". CBS. CBS Interactive Inc. January 22, 2015. Retrieved 21 February 2015.
- "Design of Endoscopic Retrograde Cholangiopancreatography (ERCP) Duodenoscopes May Impede Effective Cleaning: FDA Safety Communication". Medical Devices. US FDA. 19 February 2015. Retrieved 19 February 2015.
- Medwatch ED-530XT Duodenoscopes by FUJIFILM Medical Systems, U.S.A.: Safety Communication - FUJIFILM Medical Systems Validates Revised Reprocessing Instructions Safety alerts for Human Medical Products. U.S. FDA, 23 December 2015, retrieved 5 January 2016