Eric N. Olson

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Eric N. Olson
Eric Olson.jpg
Born (1955-09-27) September 27, 1955 (age 63)

Eric Newell Olson (born September 27, 1955 in Rochester, New York[1]) is an American molecular biologist. He is professor and chair of the Department of Molecular Biology at the University of Texas Southwestern Medical Center in Dallas, where he also holds the Robert A. Welch Distinguished Chair in Science, the Annie and Willie Nelson Professorship in Stem Cell Research, and the Pogue Distinguished Chair in Research on Cardiac Birth Defects.[2]

Biography[edit]

Dr. Olson grew up in North Carolina and attended Wake Forest University, receiving a B.A. in Chemistry and Biology, a Ph.D. in Biochemistry, and an honorary doctorate. After postdoctoral training at Washington University School of Medicine, he began his scientific career at MD Anderson Cancer Center in Houston. In 1995, he founded the Department of Molecular Biology at The University of Texas Southwestern Medical Center in Dallas.

Eric Olson has dedicated his career to deciphering the mechanisms that control development and disease of the heart, cardiovascular system and skeletal muscle tissue. He and his colleagues discovered many of the key transcription factors and mechanisms responsible for cardiac gene regulation and formation of the heart and other muscles. His work provided a genetic blueprint for tissue formation and unveiled the molecular underpinnings of congenital and acquired diseases of the heart. Olson also discovered epigenetic mechanisms and microRNAs as regulators of muscle development and disease.

Olson is among the most highly cited researchers, with his publications cited over 90,000 times in the literature.[3][4] He has trained numerous students and postdoctoral fellows, many of whom are emerging as the next generation of leaders in cardiovascular biology.

Dr. Olson co-founded multiple biotechnology companies to translate basic discoveries into new therapeutics for muscle disease. He was co-founder of Myogen, Inc., a biotechnology company focusing on therapies for heart muscle disease. In 2007, he co-founded miRagen Therapeutics, which is developing new therapeutics for cardiovascular disease, based on microRNAs.[5] In 2015, he founded Exonics Therapeutics, which is working to correct Duchenne muscular dystrophy and other muscle diseases by genome editing.[6]

In his spare time, Eric Olson plays guitar and harmonica with The Transactivators, a rock band inspired by the Texas icon, Willie Nelson, who created the Professorship that Olson holds.[7]

Awards and honors[edit]

Selected publications[edit]

  • Edmondson, D.G. and Olson, E.N. 1989. A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program. Genes Dev. 3, 628-640.
  • Gossett, L.A., Kelvin, D.J., Sternberg, E.A. and Olson, E.N. 1989. A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes. Mol. Cell. Biol. 9, 5022-5033.
  • Srivastava, D., Cserjesi, P. and Olson, E.N. 1995. New subclass of bHLH proteins required for cardiac morphogenesis. Science 270, 1995-1999.
  • Molkentin, J.D., Black, B.L., Martin, J.F. and Olson, E.N. 1995. Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell 83, 1125-1136.
  • Lin, Q., Schwarz, J. Buchana, C. and Olson, E.N. 1997. Control of mouse cardiac morphogenesis and myogenesis by the myogenic transcription factor MEF2C. Science 276, 1404-1407.
  • Molkentin, J.D., Lu, J., Antos, C.L., Markham, B., Richardson, J., Robbins, J., Grant, S. and Olson, E.N. 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215-228.
  • McKinsey, T.A., Zhang, C.L., Lu, J., and Olson, E.N. 2000. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408, 106-111.
  • Wang, D-Z., Chang, P., Wang, Z., Small, E., Krieg, P.A., Olson, E.N. 2001. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 105, 851-862.
  • Zhang, C.L., McKinsey, T.A., Chang, S., Antos, C.A., Hill, J.A., and Olson, E.N. 2002. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 110, 479-488.
  • Shin, C.H., Liu, Z.P., Passier, R., Zhang, C.L., Wang, D.Z., Harris, T.M., Yamagishi, H., Richardson, J.A., Childs, G., and Olson, E.N. 2002. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell 110, 725-735.
  • Olson, E.N. 2006. Gene regulatory networks in evolution and development of the heart. Science 313, 1922-1927.
  • van Rooij, E., Sutherland, L.B., Qi, X., Richardson, J.A., Hill, J., and Olson, E.N. 2007. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316, 575-579.
  • Williams, A.H., Valdez, G., Moresi, V., Qi, X., McAnally, J., Elliott, J.L., Bassel-Duby, R., Sanes, J.R., and Olson, E.N. 2009. MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 326, 1549-1554.

References[edit]

External links[edit]