Born in Sheboygan, Wisconsin, Keppler graduated from the University of Wisconsin and received his law degree from the University of Wisconsin Law School. Keppler served on the Sheboygan Common Council. In 1943, he served in the Wisconsin State Assembly. Keppler served in the United States Army during World War II and the Korean War. In 1961, Keppler began serving in the Wisconsin State Senate. In 1979, he was elected a Wisconsin Circuit Court judge, for Sheboygan County, Wisconsin.
Keppler was married to Bertha Keppler. They had two children, Ernest Michael Keppler and Mary Keppler (Schmidt).
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