Eshkol Regional Council is linked to Tel Aviv by bus routes 379 (Local) and route 479 (Express), to Be'er Sheva by bus route 35, and to Ashkelon by bus route 36. Inside the regional council's territory there are 6 bus routes linking the kibbutzim and the moshavim to the regional council offices. All bus routes are operated by Dan BaDarom.
The Eshkol region has been the target of thousands of rocket attacks since 2000. Despite Iron Dome coverage in the region, usage of the system is generally limited to populated areas and allows other rockets to land in open areas. As a result, there has been widespread damage to farms, vehicles and various outlying structures. During the 2014 Israel–Gaza conflict, farmers reported massive damages to their crops due to rockets landing in open fields. 
On 26 August 2014 a mortar shell fired from Gaza was reported to have killed one person and seriously wounded two others at the Eshkol Regional Council.