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Essequibo is a loosely defined region of Guyana. It may also refer to:
- Essequibo Alliance, a non-government organisation in Guyana
- Essequibo (colony), a former Dutch colony in what is now Guyana; one of the three counties of British Guiana 1838-1958
- Essequibo cricket team, a former first-class cricket team in Guyana
- Essequibo Islands-West Demerara, a region of Guyana
- Essequibo River, the largest river in Guyana
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