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Classification and external resources
Specialty oncology
ICD-10 C30.0
ICD-9-CM 160.0
ICD-O M9522/3
OMIM 133450
DiseasesDB 32047
eMedicine med/748
MeSH D018304

Esthesioneuroblastoma is a rare form of cancer involving the nasal cavity. It can cause loss of vision and taste.[1][2] It is often considered synonymous with "olfactory neuroblastoma"[3] and is believed to arise from the olfactory epithelium, but the exact tissue of origin is not yet well characterized. It is associated with trisomy 8.[4]

It was first characterized in 1924.[5][6]


According to the BBC, in 2008 only 201 cases of the disease had been recorded worldwide in the preceding two decades.[7]

A 1997 literature search identified 1,457 cases in the published literature since its discovery in 1924; however, 487 were cited in more than one paper, bringing the total of reported cases to 945.[8]


Several surgical approaches have been described,[9] [10][11][12][13] but post-excision recurrence rates have remained relatively high.

Notable cases[edit]

The disease was brought into prominence by the case of Chantal Sébire, who was suffering from the disease and ended her life after being denied euthanasia.[14]

See also[edit]


  1. ^ Sharma S, Sharma MC, Johnson MH, Lou M, Thakar A, Sarkar C (2007). "Esthesioneuroblastoma - a clinicopathologic study and role of DNA topoisomerase alpha" (Template:Date=April 2009Scholar search). Pathol. Oncol. Res. 13 (2): 123–9. doi:10.1007/BF02893487. PMID 17607373. 
  2. ^
  3. ^ "Medcyclopaedia - Esthesioneuroblastoma". Retrieved 2008-03-22. [dead link]
  4. ^ VanDevanter, D. R.; George, D; McNutt, M. A.; Vogel, A.; Luthardt, F. (1991). "Trisomy 8 in primary esthesioneuroblastoma.". Cancer Genet Cytogenet. 57 (1): 133–136. doi:10.1016/0165-4608(91)90198-4. PMID 1756479. 
  5. ^ "Esthesioneuroblastoma". Archived from the original on April 9, 2007. Retrieved 2008-03-22. 
  6. ^ Berger L, Luc G, Richard D. L'esthésioneuroépithéliome olfactif. Bull Assoc Franç Étude Cancer 1924;13:410-421.
  7. ^ "Tumour woman's death not natural". BBC News. 2008-03-21. Retrieved 2008-03-22. 
  8. ^ Broich G, Pagliari A, Ottaviani F (1997). "Esthesioneuroblastoma: a general review of the cases published since the discovery of the tumour in 1924". Anticancer Res. 17 (4A): 2683–706. PMID 9252701. 
  9. ^ Roxbury, Christopher R.; Ishii, Masaru; Gallia, Gary L.; Reh, Douglas D. (2016). "Endoscopic Management of Esthesioneuroblastoma". Otolaryngologic Clinics of North America. 49 (1): 153–165. doi:10.1016/j.otc.2015.09.010. ISSN 0030-6665. 
  10. ^ Vergani F, Pirola E, Fiori L, Pagni F, Parmigiani F, Sganzerla EP (2007). "Combined transcranial and endoscopic nasal resection for esthesioneuroblastoma. Technical note". J Neurosurg Sci. 51 (2): 99–102. PMID 17571044. 
  11. ^ Unger F, Walch C, Stammberger H, Papaefthymiou G, Haselsberger K, Pendl G (2001). "Olfactory neuroblastoma (esthesioneuroblastoma): report of six cases treated by a novel combination of endoscopic surgery and radiosurgery". Minim Invasive Neurosurg. 44 (2): 79–84. doi:10.1055/s-2001-16000. PMID 11487789. 
  12. ^ Cakmak O, Ergin NT, Yilmazer C, Kayaselçuk F, Barutcu O (2002). "Endoscopic removal of esthesioneuroblastoma". Int. J. Pediatr. Otorhinolaryngol. 64 (3): 233–8. doi:10.1016/S0165-5876(02)00036-8. PMID 12090952. 
  13. ^ Prasad KC, Kumar A, Prasad SC, Jain D (2007). "Endoscopic-assisted excision of esthesioneuroblastoma". J Craniofac Surg. 18 (5): 1034–8. doi:10.1097/scs.0b013e318157264c. PMID 17912077. 
  14. ^ Tumour woman's death not natural BBC 21 March 2008