Estradiol benzoate/testosterone propionate

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Estradiol benzoate /
testosterone propionate
Estradiol benzoate.svg
Testosterone propionate.svg
Combination of
Estradiol benzoateEstrogen
Testosterone propionateAndrogen; Anabolic steroid
Clinical data
Trade namesBothermon
Other namesEB/TP
Routes of
Intramuscular injection
CAS Number

Estradiol benzoate/testosterone propionate (EB/TP), sold under the brand name Bothermon, is an injectable combination medication of estradiol benzoate (EB), an estrogen, and testosterone propionate (TP), an androgen/anabolic steroid.[1][2][3][4][5] It contains 0.24 mg/mL EB and 4.76 mg/mL TP in oil solution in each ampoule and is administered by intramuscular injection.[1] The medication was marketed in Japan by 1953[4] and remains available in this country today.[5]

Androgen replacement therapy formulations and dosages used in women
Route Medication Major brand names Form Dosage
Oral Testosterone undecanoate Andriol, Jatenzo Capsule 40–80 mg 1x/1–2 days
Methyltestosterone Metandren, Estratest Tablet 0.5–10 mg/day
Fluoxymesterone Halotestin Tablet 1–2.5 mg 1x/1–2 days
Normethandronea Ginecoside Tablet 5 mg/day
Tibolone Livial Tablet 1.25–2.5 mg/day
Prasterone (DHEA)b Tablet 10–100 mg/day
Sublingual Methyltestosterone Metandren Tablet 0.25 mg/day
Transdermal Testosterone Intrinsa Patch 150–300 μg/day
AndroGel Gel, cream 1–10 mg/day
Vaginal Prasterone (DHEA) Intrarosa Insert 6.5 mg/day
Injection Testosterone propionatea Testoviron Oil solution 25 mg 1x/1–2 weeks
Testosterone enanthate Delatestryl, Primodian Depot Oil solution 25–100 mg 1x/4–6 weeks
Testosterone cypionate Depo-Testosterone, Depo-Testadiol Oil solution 25–100 mg 1x/4–6 weeks
Testosterone isobutyratea Femandren M, Folivirin Aqueous suspension 25–50 mg 1x/4–6 weeks
Mixed testosterone esters Climacterona Oil solution 150 mg 1x/4–8 weeks
Omnadren, Sustanon Oil solution 50–100 mg 1x/4–6 weeks
Nandrolone decanoate Deca-Durabolin Oil solution 25–50 mg 1x/6–12 weeks
Prasterone enanthatea Gynodian Depot Oil solution 200 mg 1x/4–6 weeks
Implant Testosterone Testopel Pellet 50–100 mg 1x/3–6 months
Notes: Premenopausal women produce about 230 ± 70 μg testosterone per day (6.4 ± 2.0 mg testosterone per 4 weeks), with a range of 130 to 330 μg per day (3.6–9.2 mg per 4 weeks). Footnotes: a = Mostly discontinued or unavailable. b = Over-the-counter. Sources: See template.

See also[edit]


  1. ^ a b 伴一郎, & 杉山陽一. (1956). 男性ホルモンと黄体ホルモンとの混合製剤 Testoluton の使用成績. [Testoluton (Schering), A Combined Preparation of Testosterone Propionate and Progesterone Applied for Clinical Use] 産婦人科の進歩, 8(2), 100-103.
  2. ^ 村上清. (1959). 産科婦人科的ホルモン療法の概況 (本邦). [Overview of obstetrics and gynecology hormone therapy (in Japan).] 産婦人科の進歩, 11(Special), 6-30.
  3. ^ 山村博三. (1956). 機能性子宮出血の性ホルモン療法. [Sex hormone therapy for functional uterine bleeding.] 関西医科大学雑誌, 8(4), 293-299.
  4. ^ a b 植田安雄, & 辻井翠. (1953). 月経困難症に対する Androgenestrogen 混合剤 Bothermon の応用 (治療成績). [Application of Androgenestrogen Bothermon for dysmenorrhea (treatment results).] ホルモンと臨床, 1(4), 333-337.
  5. ^ a b "Archived copy". Archived from the original on 2019-04-07. Retrieved 2019-06-09.{{cite web}}: CS1 maint: archived copy as title (link)