Estradiol dibutyrate

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Estradiol dibutyrate
Estradiol dibutyrate.svg
Clinical data
Other namesEDBu; Estradiol dibutanoate; Estradiol 3,17β-dibutanoate
Routes of
Intramuscular injection
Drug classEstrogen; Estrogen ester
CAS Number
CompTox Dashboard (EPA)
ECHA InfoCard100.057.990 Edit this at Wikidata
Chemical and physical data
Molar mass412.570 g·mol−1
3D model (JSmol)
  • O(C(CCC)=O)[C@]1CC[C@]([H])2[C@@]([H])3CCC4C=C(C=CC=4[C@@]3([H])CC[C@@]21C)OC(=O)CCC
  • InChI=1S/C26H35O4/c1-4-6-24(27)29-18-9-11-19-17(16-18)8-10-21-20(19)14-15-26(3)22(21)12-13-23(26)30-25(28)7-5-2/h9,11,16,20-22H,4-8,10,12-15H2,1-3H3/t20-,21-,22+,26+/m1/s1

Estradiol dibutyrate (EDBu), or estradiol dibutanoate, is an estrogen medication and an estrogen ester – specifically, a diester of estradiol – which is no longer used.[1][2] It was a component of Triormon Depositum, a combination formulation of estradiol dibutyrate, testosterone caproate, and hydroxyprogesterone heptanoate which was developed in the 1950s.[2]

See also[edit]


  1. ^ Cacciari P (August 1960). "[Experimental research on estradiol dibutyrate]". Minerva Ginecol (in Italian). 12: 788–9. PMID 13689684.
  2. ^ a b Ermiglia, G; Valli, P (1957). "Triormon depositum in climacteric syndrome. Curves of excretion of catabolites and duration of the therapeutic effect". Quaderni Clin. Ostet. E Ginecol. 12: 284–93. Triormon depositum (estradiol dibutyrate 3, testosterone caprylate 50, and hydroxyprogesterone heptanoate 30 mg.), administered in castor oil-benzyl benzoate soln. or polyvinylpyrrolidone suspension to 21 women in climacteric, was followed by estradiol, pregnanediol, and 17-keto steroid urinary curves, most with a peak at the 4th day, and approaching starting values at the 8-10th day. The therapeutic efficacy of the drug was satisfactory.