Estradiol enanthate

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Estradiol enanthate
Estradiol enanthate.png
Systematic (IUPAC) name
(17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl heptanoate
Clinical data
Routes of
administration
IM
Legal status
Legal status
  • ℞ (Prescription only)
Identifiers
CAS Number 4956-37-0
ATC code None
PubChem CID 21070
ChemSpider 19815
ChEMBL CHEMBL1697792
Synonyms 17β-Estradiol-17-heptanoate
Chemical data
Formula C25H36O3
Molar mass 384.552 g/mol

Estradiol enanthate (INN, USAN), or estradiol enantate, is a synthetic ester, specifically the 17-heptanoyl ester, of the natural estrogen, estradiol.[1][2] It is marketed under the brand names Anafertin, Deladroxate, Perlutan, and Topasel, which are combination formulations of estradiol enanthate and dihydroxyprogesterone acetophenide, as a once-monthly injectable hormonal contraceptive in Spain and Latin America,[3][4] and has been used as such since at least the mid-1960s.[5] A 10 mg dose of estradiol enanthate via intramuscular injection has been found to result in elevated estradiol levels for up to 31 days.[6]

See also[edit]

References[edit]

  1. ^ A. D. Roberts (1991). Dictionary of Steroids: Chemical Data, Structures, and Bibliographies. CRC Press. p. 415. ISBN 978-0-412-27060-4. Retrieved 20 May 2012. 
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 405. ISBN 978-3-88763-075-1. Retrieved 20 May 2012. 
  3. ^ Zutshi (1 January 2005). Hormones in Obstetrics and Gynaecology. Jaypee Brothers Publishers. p. 138. ISBN 978-81-8061-427-9. Retrieved 20 May 2012. 
  4. ^ Newton JR, D'arcangues C, Hall PE (1994). "A review of "once-a-month" combined injectable contraceptives". Journal of Obstetrics and Gynaecology. 4 Suppl 1: S1–34. doi:10.3109/01443619409027641. PMID 12290848. 
  5. ^ Rizkallah TH, Taymor ML (January 1966). "Ovulation inhibition with a log-acting injectable. II. The cycling effects of varying progestagen-estrogen combinations". American Journal of Obstetrics and Gynecology. 94 (2): 161–4. PMID 5900652. 
  6. ^ Michael Oettel; Ekkehard Schillinger (6 December 2012). Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen. Springer Science & Business Media. pp. 271–. ISBN 978-3-642-60107-1.