Estradiol valerate/dienogest

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Estradiol valerate / dienogest
Estradiol valerate.svg
Estradiol valerate (top) and
dienogest (bottom)
Combination of
Estradiol valerateEstrogen
Clinical data
Trade namesLafamme, Natazia, Qlaira
Other namesEV/DNG; SH T00658ID; Bay 86-5027; BAY86-5027
AHFS/Drugs.comProfessional Drug Facts
License data
Routes of
By mouth
Drug classEstrogen; Progestogen
ATC code
Legal status
Legal status
CAS Number
PubChem CID

Estradiol valerate/dienogest (EV/DNG), sold under the brand names Lafamme, Natazia and Qlaira among others, is a combination product of estradiol valerate, an estrogen, and dienogest, a progestogen, which is used in menopausal hormone therapy in and as a birth control pill to prevent pregnancy in women. It is taken by mouth.

Birth control pills containing EV/DNG are associated with a significantly increased risk of venous thromboembolism.[2] However, they are associated with a significantly lower risk of venous thromboembolism than birth control pills containing ethinylestradiol and a progestin.[2]

See also[edit]


  1. ^ a b c "Dienogest / estradiol (Natazia) Use During Pregnancy". 27 January 2020. Retrieved 18 March 2020.
  2. ^ a b Fruzzetti F, Cagnacci A (2018). "Venous thrombosis and hormonal contraception: what's new with estradiol-based hormonal contraceptives?". Open Access J Contracept. 9: 75–79. doi:10.2147/OAJC.S179673. PMC 6239102. PMID 30519125.

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