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Skeletal formula of estramustine
Ball-and-stick model of the estramustine molecule
Systematic (IUPAC) name
(17β)-17-Hydroxyestra-1(10),2,4-trien-3-yl bis(2-chloroethyl)carbamate
Clinical data
Trade names Emcyt
AHFS/ Monograph
MedlinePlus a608046
License data
  • AU: D
  • US: X (Contraindicated)
Legal status
Legal status
Pharmacokinetic data
Bioavailability 75%[1]
Metabolism Hepatic to estradiol and estrone[1]
Biological half-life 15-24 hours[1]
Excretion Faeces (2.9-4.8%)[1]
CAS Number 2998-57-4 YesY
ATC code L01XX11 (WHO)
PubChem CID 259331
DrugBank DB01196 YesY
ChemSpider 227635 YesY
UNII 35LT29625A YesY
KEGG D04066 YesY
Chemical data
Formula C23H31Cl2NO3
Molar mass 440.403 g/mol

Estramustine (INN, USAN, BAN) (brand names Emcyt, Estracit), in salt form as estramustine phosphate sodium (USAN) (or estramustine sodium phosphate (BAN)) or estramustine phosphate meglumine, is an alkylating antineoplastic agent (that is, a chemotherapeutic) that is used in the treatment of prostate cancer throughout the world.[2] It is a derivative of estradiol, an estrogen, with a nitrogen mustard-carbamate ester moiety attached. The drug has been withdrawn from a number of markets, including Australia, Brazil, Ireland, and Norway.[3]

Clinical uses[edit]

Estramustine is indicated, in the US, for the palliative treatment of metastatic and/or progressive prostate cancer.[1] Whereas in the UK it is indicated for the treatment of unresponsive or relapsing prostate cancer.[4][5][6][7]

Adverse effects[edit]

Adverse effects by frequency:[1][4]
Very common (>10% frequency):

  • Oedema
  • Dyspnoea
  • Nausea
  • Diarrhoea
  • Breast tenderness and enlargement

Common (1-10% frequency):

Rare (<0.1% frequency):

  • Angiooedema, occurs most commonly when used in combination with ACE inhibitors.

Unlike other nitrogen mustards it seldom produces significant GI or haematologic toxicity such as myelosuppression,[5] the major drug toxicity-related cause of drug discontinuation is thromboembolism (blood clots).[8]


It is contraindicated when used in children, patients hypersensitive to estradiol or nitrogen mustards, those with peptic ulcer (an ulcer in the digestive tract), those with severely compromised liver function, those with weak heart muscle (also known as myocardial insufficiency) and those with thromboembolic disorders or complications related to fluid retention.[4]


Estrogen mimics like estramustine have been reported to increase the toxicity and therapeutic efficacy of tricyclic antidepressants like amitriptyline and imipramine.[4] Dairy products and other products containing calcium, aluminium and magnesium have been reported to reduce the absorption of estramustine from the gastrointestinal tract hence reducing bioavailability.[4] There may be an increased risk of angiooedema in those concurrently taking ACE inhibitors.[4]

Mechanism of action[edit]

Its therapeutic actions are believed to be related to its ability to depolymerising the microtubules (which it achieves by binding to microtubule associated proteins), this arrests prostate cancer cells in the G2/M phase of the cell cycle.[5][6][7] It is selectively taken up by prostate cells and hence produces minimal cytotoxic effects on healthy tissue.[5]


Estramustine is delivered as an oral capsule. It is readily taken up from the gastrointestinal tract and then rapidly dephosphorylated from estramustine phosphate to estramustine.[5] Estramustine is then partially oxidized to estromustine.[5] Some estramustine and estromustine undergoes hydrolysis at the ester bond in the liver to form estradiol, estrone and normustine.[5] Milk, calcium, aluminium and magnesium supplements may reduce bioavailability.[4]

Active metabolites of estramustine
Estramustine Estromustine Estradiol Estrone Normustine
Estrone structure.svg

See also[edit]


  1. ^ a b c d e f "Emcyt (estramustine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 8 February 2014. 
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 406–407. ISBN 978-3-88763-075-1. 
  3. ^ Sweetman, S, ed. (12 February 2013). "Estramustine Sodium Phosphate". Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. Retrieved 8 February 2014. 
  4. ^ a b c d e f g "Estracyt Capsules - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Pfizer Limited. 12 August 2013. Retrieved 8 February 2014. 
  5. ^ a b c d e f g Perry, CM; McTavish, D (July 1995). "Estramustine Phosphate Sodium". Drugs & Aging. 7 (1): 49–74. doi:10.2165/00002512-199507010-00006. PMID 7579781. 
  6. ^ a b Bergenheim, AT; Henriksson, R (February 1998). "Pharmacokinetics and pharmacodynamics of estramustine phosphate.". Clinical pharmacokinetics. 34 (2): 163–72. doi:10.2165/00003088-199834020-00004. PMID 9515186. 
  7. ^ a b Simpson, D; Wagstaff, AJ (2003). "Estramustine Phosphate Sodium". American Journal of Cancer. 2 (5): 373–390. doi:10.2165/00024669-200302050-00013. 
  8. ^ Fizazi K, Le Maitre A, Hudes G, Berry WR, Kelly WK, Eymard JC, Logothetis CJ, Pignon JP, Michiels S (2007). "Addition of estramustine to chemotherapy and survival of patients with castration-refractory prostate cancer: a meta-analysis of individual patient data". Lancet Oncol. 8 (11): 994–1000. doi:10.1016/S1470-2045(07)70284-X. PMID 17942366. 

External links[edit]