|Synonyms||EM; EaM; Leo 275; Ro 21-8837; Estradiol 3-(bis(2-chloroethyl)carbamate) ester; Estra-1,3,5(10)-triene-3,17β-diol 3-(bis(2-chloroethyl)carbamate) ester|
|Drug class||Nitrogen mustard; Alkylating antineoplastic agent; Estrogen; Estrogen ester|
|Chemical and physical data|
|Molar mass||440.405 g/mol|
|3D model (JSmol)|
Estramustine (INN, USAN, BAN) is a estrogen and cytostatic antineoplastic agent which was never marketed. It is an estrogen ester – specifically, the C3 normustine ester of estradiol – and acts in part as a prodrug of estradiol in the body. Estramustine phosphate, the C17β phosphate ester of estramustine and a prodrug of estramustine, estromustine, estradiol, and estrone, is marketed and used in the treatment of prostate cancer.
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