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This article is about a non-clinically used compound. For the pharmaceutical drug, see estramustine phosphate.
Skeletal formula of estramustine
Ball-and-stick model of the estramustine molecule
Synonyms Leo 275; Ro 21-8837; Estradiol 3-(bis(2-chloroethyl)carbamate) ester; Estra-1,3,5(10)-triene-3,17β-diol 3-(bis(2-chloroethyl)carbamate) ester
CAS Number 2998-57-4
PubChem (CID) 259331
ChemSpider 227635
UNII 35LT29625A
KEGG D04066
Chemical and physical data
Formula C23H31Cl2NO3
Molar mass 440.405 g/mol
3D model (Jmol) Interactive image

Estramustine (INN, USAN, BAN) is a synthetic steroidal estrogen and alkylating antineoplastic agent that was never marketed.[1][2] It is an estrogen ester – specifically, the C3 normustine ester of estradiol – and acts as a prodrug to estradiol and normustine in the body.[1][2] Estramustine phosphate, the C17β phosphate ester of estramustine, is marketed and used in the treatment of prostate cancer.[1][2]

See also[edit]


  1. ^ a b c J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 502–. ISBN 978-1-4757-2085-3. 
  2. ^ a b c Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 406–. ISBN 978-3-88763-075-1.