Estramustine

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Estramustine
Skeletal formula of estramustine
Ball-and-stick model of the estramustine molecule
Clinical data
SynonymsEM; EaM; Leo 275; Ro 21-8837; Estradiol 3-(bis(2-chloroethyl)carbamate) ester; Estra-1,3,5(10)-triene-3,17β-diol 3-(bis(2-chloroethyl)carbamate) ester
Drug classNitrogen mustard; Alkylating antineoplastic agent; Estrogen; Estrogen ester
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.019.161 Edit this at Wikidata
Chemical and physical data
FormulaC23H31Cl2NO3
Molar mass440.405 g/mol
3D model (JSmol)

Estramustine (INN, USAN, BAN) is a estrogen and cytostatic antineoplastic agent which was never marketed.[1][2] It is an estrogen ester – specifically, the C3 normustine ester of estradiol – and acts in part as a prodrug of estradiol in the body.[1][2] Estramustine phosphate, the C17β phosphate ester of estramustine and a prodrug of estramustine, estromustine, estradiol, and estrone, is marketed and used in the treatment of prostate cancer.[1][2]

See also[edit]

References[edit]

  1. ^ a b c J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 502–. ISBN 978-1-4757-2085-3.
  2. ^ a b c Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 406–. ISBN 978-3-88763-075-1.