Estrapronicate/hydroxyprogesterone heptanoate/nandrolone undecanoate ( EPC/OHPH/NU), tentative brand name Trophobolene or Trophoboline, is an injectable combination medication of estrapronicate (EPC; estradiol nicotinate propionate), an estrogen, hydroxyprogesterone heptanoate (OHPH), a progestogen, and nandrolone undecanoate (NU), an androgen/ anabolic steroid, which was never marketed.    It contained 1.3 mg EPC, 80 mg OHPH, and 50 mg NU in  oil solution and was administered by intramuscular injection.   The medication was developed by Théramex in the mid-to-late 1960s.    It was studied for use for a variety of indications, including treatment of  coronary insufficiency, growth deficiency, and osteoporosis, as well as hormonal disorders in gonadotropin deficiency.
In contrast to other
anabolic steroid-containing preparations, EPC/OHPH/NU reportedly had no masculinizing effects, and its estrogenic component likewise reportedly had no feminizing effects. The  nicotinic acid (niacin; vitamin B3) derived from estrapronicate was said to enhance the nutrient, relaxant, and antiadipose effects of the estrogenic component.
pharmacokinetics of nandrolone undecanoate in this combination preparation have been studied as well as compared to nandrolone alone (Dynabolon).
See also [ edit ]
References [ edit ]
^ a b c d e f
. Państwowy Zakład Wydawnuictw Lekarskich. 1969. p. 210. Polish Endocrinology
^ a b c
Vignon G, Pansu D (15 January 1967). "Le traitement de l'ostéoporose par le trophobolène" [The treatment of osteoporosis by trophobolene]. Rev Lyon Med (in French). 16 (1): 31–8. ISSN 0556-798X. PMID 5595570.
. ScholarlyEditions. 21 June 2013. pp. 137–. Testosterone Congeners—Advances in Research and Application: 2013 Edition: ScholarlyBrief ISBN . 978-1-4816-9288-5 Table 1 Oil based long-acting intramuscular injections products [...] Trophobolene: Estrapronicate 1.3 mg [...] Nandrolone undecanoate 50 mg Hydroxyprogesterone heptanoate 80 mg.
Axel Kleemann; Jürgen Engel (2001). . Thieme. p. 1397. Pharmaceutical substances: syntheses, patents, applications ISBN . 978-3-13-558404-1
Courtot, D; Forichon, J; Paris, J (1983). "Pharmacokinetics of 19-Nortestosterone in Man". . Analytical Chemistry Symposia Series. Vol. 13. Amsterdam/Oxford/New York: Elsevier. pp. 95–110. Chromatography in Biochemistry, Medicine, and Environmental Research, 1: Proceedings of the 1st International Symposium on Chromatography in Biochemistry, Medicine and Environmental Research, Venice, June 16–17, 1981