Estrogen dominance

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Estrogen dominance is a theory about a metabolic state where the level of estrogen outweighs the level of progesterone in the body. This is said to be caused by a decrease in progesterone without a subsequent decrease in estrogen. The theory is popular among natural health practitioners, but is generally not recognized by mainstream medicine. [1]

The theory was proposed by John R. Lee and Virginia Hopkins in their 1996 book, What Your Doctor May Not Tell You About Menopause: The Breakthrough Book on Natural Progesterone.[2] This book criticized estrogen replacement therapy and proposed the use of "natural progesterone" for menopausal women in order to alleviate a variety of complaints. It has also been promoted by Ronald Hoffman, who hosts the "Health Talk" radio show.[3] Lee's theories have been criticized for being inadequately supported through science, being primarily based on anecdotal evidence with no rigorous research to support them.[4]


  1. ^ NYC Holistic Health & Wellness Practitioner "Estrogen Dominance". 
  2. ^ New York: Warner Books. "I would propose that a new syndrome be recognized: estrogen dominance." p. 41
  3. ^ Hoffman, Ronald. "Estrogen dominance syndrome". Retrieved 2009-08-14. 
  4. ^ Watt PJ, Hughes RB, Rettew LB, Adams R (2003). "A holistic programmatic approach to natural hormone replacement". Fam Community Health. 26 (1): 53–63. PMID 12802128. doi:10.1097/00003727-200301000-00007.