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Monoclonal antibody
TypeWhole antibody
SourceHumanized (from mouse)
Targetalpha-v beta-3 integrin
Clinical data
Trade namesAbegrin
ATC code
  • none
CAS Number
  • none
Chemical and physical data
Molar mass144.3 kg/mol g·mol−1
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Etaracizumab (also known as etaratuzumab[citation needed], MEDI-522, trade name Abegrin) is a humanized monoclonal antibody which is being investigated for the treatment of metastatic melanoma, prostate cancer,[1] ovarian cancer[2] and various other types of cancer.[3] It is manufactured by MedImmune.[1]

Adverse drug effects[edit]


  1. ^ a b Statement On A Nonproprietary Name Adopted By The Usan Council: Etaracizumab
  2. ^ Landen, CN; Kim, TJ; Lin, YG; Merritt, WM; Kamat, AA; Han, LY; Spannuth, WA; Nick, AM; Jennnings, NB (2008). "Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancer". Neoplasia. 10 (11): 1259–67. doi:10.1593/neo.08740. PMC 2570602. PMID 18953435.
  3. ^ Delbaldo, C; Raymond, E; Vera, K; Hammershaimb, L; Kaucic, K; Lozahic, S; Marty, M; Faivre, S (2008). "Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors". Investigational new drugs. 26 (1): 35–43. doi:10.1007/s10637-007-9077-0. PMID 17876527.