Etazocine

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Etazocine
Etazocine structure.svg
Systematic (IUPAC) name
1,2,3,4,5,6-hexahydro-6,11-diethyl-3-methyl-2,6-methano-3-benzazocin-8-ol
or
5,7-diethyl-2-hydroxy-2-methyl-6,7-benzomorphan
Legal status
Legal status
  • Non-regulated
Identifiers
CAS Number 34254-87-0
10286-45-0 ((−)-form (HCl))
ATC code None
PubChem CID 187767
ChemSpider 163214
Synonyms NIH-7856 ((±)-form);
GPA-208 ((−)-form);
GPA-2087 ((−)-form);
NIH-8178 ((−)-form);
FDA-0487 ((−)-form)
Chemical data
Formula C17H25NO
Molar mass 259.387 g/mol

Etazocine (NIH-7856) is an opioid analgesic of the benzomorphan family which was never marketed.[1][2] It acts as a partial agonist of the opioid receptors, with mixed agonist and antagonist effects.[1] In animal studies, it was shown to induce analgesia, dependency, and respiratory depression, with overall effects similar to those of morphine, but with substantially reduced potency in comparison.[1][2][3]

See also[edit]

References[edit]

  1. ^ a b c National Research Council (U.S.). Committee on Problems of Drug Dependence, American Medical Association. Committee on Alcoholism and Drug Dependence, American Medical Association. Council on Mental Health, National Academy of Sciences (U.S.) (1969). Bulletin, problems of drug dependence. National Academies. pp. 5820–5821. NAP:10503. Retrieved 22 April 2012. 
  2. ^ a b Smethurst PW, Forrest WH, Hayden J (December 1971). "The respiratory effects of a potent analgesic (GPA 2087) in man". British Journal of Anaesthesia. 43 (12): 1129–35. doi:10.1093/bja/43.12.1129. PMID 5156297. 
  3. ^ National Research Council (U.S.). Committee on Problems of Drug Dependence (1970). Report of the annual scientific meeting. National Research Council. Retrieved 22 April 2012.