Ethacridine lactate

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Ethacridine lactate
Skeletal formulas of ethacridine lactate
Ball-and-stick models of the component ions of ethacridine lactate
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
ChEMBL
ECHA InfoCard 100.015.826 Edit this at Wikidata
Chemical and physical data
Formula C18H21N3O4
Molar mass 343.37
3D model (JSmol)
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Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Its primary use is as an antiseptic[1] in solutions of 0.1%. It is effective against mostly Gram-positive bacteria, such as Streptococci and Staphylococci, but ineffective against Gram-negative bacteria such as Pseudomonas aeruginosa.[2]

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used.[3] Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.

References[edit]

  1. ^ Merck Index, 11th Ed., 3668
  2. ^ Adarchenko AA, Krasil'nikov AP, Sobeshchuk OP (1989). "[Antiseptic sensitivity of clinical strains of Pseudomonas aeruginosa]". Antibiotiki i Khimioterapiia (in Russian). 34 (12): 902–7. PMID 2517004.
  3. ^ Tien, K. H. (1983). "Intraamniotic injection of ethacridine for second-trimester induction of labor". Obstetrics and gynecology. 61 (6): 733–736. PMID 6843933.