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Combination of
EthambutolAnti-tuberculosis medication
IsoniazidAnti-tuberculosis medication
PyrazinamideAnti-tuberculosis medication
RifampicinAnti-tuberculosis medication
Clinical data
Trade namesVoractiv, Rimstar, others
ATC code
  • none

Ethambutol/isoniazid/pyrazinamide/rifampicin, also known as ethambutol/isoniazid/pyrazinamide/rifampin, is a medication used for tuberculosis.[1] It is a fixed dose combination of ethambutol, isoniazid, pyrazinamide, and rifampicin.[1] It is used either alone or with other antituberculosis medication.[1] It is taken by mouth.[1]

Side effects are those of the underlying medications.[1] Pyridoxine may be used to decrease the risk of numbness.[2] It is not recommended in people with liver problems or severe kidney problems.[3] Use may not be suitable in children.[1] It is unclear if use during pregnancy is safe.[3]

It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[4] In the United Kingdom it costs the NHS 98.75 pounds for a typical month of medication as of 2015.[2] It is sold under the brand names Voractiv and Rimstar in the UK.[3]


  1. ^ a b c d e f WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 142. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
  2. ^ a b British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 403. ISBN 9780857111562.
  3. ^ a b c "Rimstar Film-coated Tablet / Voractiv Film-coated Tablet - Summary of Product Characteristics (SPC) - (eMC)". February 2016. Archived from the original on 20 December 2016. Retrieved 18 December 2016.
  4. ^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.