|Synonyms||EE3; 17α-Ethynylestriol; 17α-Ethynylestra-1,3,5(10)-triene-3,16α,17β-triol|
|Chemical and physical data|
|Molar mass||312.409 g·mol−1|
|3D model (JSmol)|
Ethinylestriol (EE3), or 17α-ethynylestriol, also known as 17α-ethynylestra-1,3,5(10)-triene-3,16α,17β-triol, is a synthetic estrogen which was never marketed. Nilestriol, the 3-cyclopentyl ether of ethinylestriol, is a prodrug of ethinylestriol, and is a more potent estrogen in comparison, but, in contrast to ethinylestriol, has been marketed. Ethinylestriol has been found to reduce the risk of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary cancer when given as a prophylactic in animal models, while other estrogens like ethinylestradiol and diethylstilbestrol were ineffective.
- William McGuire (14 December 2013). Experimental Biology. Springer Science & Business Media. pp. 161–. ISBN 978-1-4757-4673-0.
- J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 891–. ISBN 978-1-4757-2085-3.
- Lemon, Henry M. (15 December 1987). "Antimammary carcinogenic activity of 17-alpha-ethinyl estriol". Cancer. 60 (12): 2873–2881. doi:10.1002/1097-0142(19871215)60:12<2873::AID-CNCR2820601204>3.0.CO;2-B. ISSN 1097-0142. PMID 3119187.
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