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Ethylmethylthiambutene structure.svg
Clinical data
ATC code none
Legal status
Legal status
CAS Number 441-61-2
PubChem (CID) 46424
DrugBank DB01468 YesY
ChemSpider 42256 YesY
UNII 722BFZ899Q YesY
Chemical and physical data
Formula C15H19NS2
Molar mass 277.45 g/mol
3D model (Jmol) Interactive image

Ethylmethylthiambutene (N-ethyl-N-methyl-1-methyl-3,3-di-2-thienylallylamine; Emethibutin) is an opioid analgesic drug from the thiambutene family, around 1.3x the potency of morphine.[1][2][3] It is under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse potential. It is a Schedule I controlled substance in the United States with a DEA ACSCN of 9623 and zero annual manufacturing quota as of 2013.[citation needed]


  1. ^ Adamson, DW; Green, AF (1950). "A new series of analgesics". Nature. 165 (4186): 122–122. doi:10.1038/165122a0. PMID 15409854. 
  2. ^ Adamson, DW; Duffin, WM; Green, AF (1951). "Dithienylbutylamines as analgesics". Nature. 167 (4239): 153–4. doi:10.1038/167153b0. PMID 14806409. 
  3. ^ Green, AF (1953). "Analgesic and other properties of 3: 3-dithienylalkenylamines". British journal of pharmacology and chemotherapy. 8 (1): 2–9. doi:10.1111/j.1476-5381.1953.tb00739.x. PMC 1509239Freely accessible. PMID 13066683.