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Structural formula
Ball-and-stick model
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
  • 7,8-didehydro-4,5-α-epoxy- 3-ethoxy-17-methylmorphinan-6-α-ol
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.000.883 Edit this at Wikidata
Chemical and physical data
Molar mass313.397 g·mol−1
3D model (JSmol)
  • O[C@H]2\C=C/[C@H]5[C@@H]4N(CC[C@@]51c3c(O[C@H]12)c(OCC)ccc3C4)C
  • InChI=1S/C19H23NO3/c1-3-22-15-7-4-11-10-13-12-5-6-14(21)18-19(12,8-9-20(13)2)16(11)17(15)23-18/h4-7,12-14,18,21H,3,8-10H2,1-2H3/t12-,13+,14-,18-,19-/m0/s1 checkY

Ethylmorphine (also known as codethyline, dionine, and ethyl morphine) is an opioid analgesic and antitussive.[1][2][3][4][5][6]

See also[edit]


  1. ^ Xu BQ, Aasmundstad TA, Lillekjendlie B, Bjørneboe A, Christophersen AS, Mørland J (April 1997). "Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model". Pharmacology & Toxicology. 80 (4): 171–81. doi:10.1111/j.1600-0773.1997.tb00392.x. PMID 9140136.
  2. ^ Jonasson B, Jonasson U, Holmgren P, Saldeen T (August 1999). "Fatal poisonings where ethylmorphine from antitussive medications contributed to death". International Journal of Legal Medicine. 112 (5): 299–302. doi:10.1007/s004140050253. PMID 10460420. S2CID 24384512.
  3. ^ Popa C, Beck O, Brodin K (March–April 1998). "Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine". Journal of Analytical Toxicology. 22 (2): 142–7. doi:10.1093/jat/22.2.142. PMID 9547411.
  4. ^ Amacher DE, Schomaker SJ (January 1998). "Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters. 94 (2): 115–25. doi:10.1016/S0378-4274(97)00108-2. PMID 9574808.
  5. ^ Aasmundstad TA, Xu BQ, Johansson I, Ripel A, Bjørneboe A, Christophersen AS, et al. (June 1995). "Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose". British Journal of Clinical Pharmacology. 39 (6): 611–20. doi:10.1111/j.1365-2125.1995.tb05720.x. PMC 1365072. PMID 7654478.
  6. ^ Liu Z, Mortimer O, Smith CA, Wolf CR, Rane A (January 1995). "Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism". British Journal of Clinical Pharmacology. 39 (1): 77–80. doi:10.1111/j.1365-2125.1995.tb04413.x. PMC 1364985. PMID 7756104.