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Systematic (IUPAC) name
7,8-didehydro-4,5-α-epoxy- 3-ethoxy-17-methylmorphinan-6-α-ol
Clinical data
AHFS/ International Drug Names
Legal status
Legal status
CAS Number 76-58-4 YesY
ATC code R05DA01 (WHO) S01XA06 (WHO)
PubChem CID 5359271
DrugBank DB01466 YesY
ChemSpider 4514250 YesY
Chemical data
Formula C19H23NO3
Molar mass 313.391 g/mol

Ethylmorphine (also known as codethyline, dionine, and ethyl morphine) is an opioid analgesic and antitussive.[1][2][3][4][5][6]

See also[edit]


  1. ^ Xu, Bang Qian; Aasmundstad, Tor A.; Lillekjendlie, Bjern; Bjørneboe, Anders; Christophersen, Asbjørg S.; Mørland, Jørg (April 1997). "Effects of Ethanol on Ethylmorphine Metabolism in Isolated Rat Hepatocytes: Characterization by Means of a Multicompartmental Model". Pharmacology & Toxicology. 80 (4): 171–181. doi:10.1111/j.1600-0773.1997.tb00392.x. ISSN 1600-0773. PMID 9140136. 
  2. ^ Jonasson, B.; Jonasson, U.; Holmgren, P.; Saldeen, T. (August 1999). "Fatal poisonings where ethylmorphine from antitussive medications contributed to death". International Journal of Legal Medicine. 112 (5): 299–302. doi:10.1007/s004140050253. ISSN 1437-1596. PMID 10460420. 
  3. ^ Popa, Cornelia; Beck, Olof; Brodin, Kerstin (March–April 1998). "Morphine Formation from Ethylmorphine: Implications for Drugs-of-Abuse Testing in Urine". Journal of Analytical Toxicology. 22 (2): 142–147. doi:10.1093/jat/22.2.142. ISSN 1945-2403. PMID 9547411. 
  4. ^ Amacher, David E; Schomaker, Shelli J (31 January 1998). "Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters. 94 (2): 115–125. doi:10.1016/S0378-4274(97)00108-2. PMID 9574808. 
  5. ^ Aasmundstad, Ta; Xu, Bq; Johansson, I.; Ripel, A.; Bjorneboe, A.; Christophersen, As; Bodd, E.; Morland, J. (June 1995). "Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose.". British Journal of Clinical Pharmacology. 39 (6): 611–620. doi:10.1111/j.1365-2125.1995.tb05720.x. ISSN 1365-2125. PMC 1365072free to read. PMID 7654478. 
  6. ^ Liu, Z; Mortimer, O; Smith, Ca; Wolf, Cr; Rane, A (January 1995). "Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism.". British Journal of Clinical Pharmacology. 39 (1): 77–80. doi:10.1111/j.1365-2125.1995.tb04413.x. ISSN 1365-2125. PMC 1364985free to read. PMID 7756104.