Ethyltestosterone
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| Routes of administration |
Oral |
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| Formula | C21H32O2 |
| Molar mass | 316.47758 g/mol |
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Ethyltestosterone, or 17α-ethyltestosterone, also known as 17α-ethylandrost-4-en-17β-ol-3-one or 17α-pregn-4-en-17-ol-3-one, is a synthetic, orally active anabolic-androgenic steroid (AAS) of the 17α-alkylated group related to methyltestosterone which was never marketed.[1][2] Like methyltestosterone, ethyltestosterone is the parent compound of many AAS.[3] Derivatives of ethyltestosterone include norethandrolone (ethylnandrolone, ethylestrenolone), ethylestrenol (ethylnandrol), norboletone, ethyldienolone, tetrahydrogestrinone, bolenol (ethylnorandrostenol), and propetandrol.[3]
Ethyltestosterone is described as a very weak AAS[4] and is considerably weaker as an AAS than is methyltestosterone.[5] Analogues with longer C17α chains such as propyltestosterone (topterone) have further greatly reduced androgenic activity or even antiandrogenic activity.[2][6] In contrast to ethyltestosterone, its 19-demethyl variant, norethandrolone, is a potent AAS comparable in anabolic activity to testosterone propionate.[4]
See also[edit]
References[edit]
- ^ R.A. Hill; H.L.J. Makin; D.N. Kirk; G.M. Murphy (23 May 1991). Dictionary of Steroids. CRC Press. pp. 423–. ISBN 978-0-412-27060-4.
- ^ a b Saunders, Francis J.; Drill, Victor A. (1956). "THE MYOTROPHIC AND ANDROGENIC EFFECTS OF 17-ETHYL-19-NORTESTOSTERONE AND RELATED COMPOUNDS". Endocrinology. 58 (5): 567–572. ISSN 0013-7227. PMID 13317831. doi:10.1210/endo-58-5-567.
- ^ a b Shahidi NT (2001). "A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids". Clin Ther. 23 (9): 1355–90. PMID 11589254. doi:10.1016/s0149-2918(01)80114-4.
- ^ a b Colton, Frank B.; Nysted, Leonard N.; Riegel, Byron; Raymond, Albert L (1957). "17-Alkyl-19-nortestosterones". Journal of the American Chemical Society. 79 (5): 1123–1127. ISSN 0002-7863. doi:10.1021/ja01562a028.
- ^ Srinivasa Rangaswami; Tiruvenkata Rajendra Seshadri (1952). Chemistry of vitamins and hormones. Andhra Univ.
- ^ Singh SM, Gauthier S, Labrie F (2000). "Androgen receptor antagonists (antiandrogens): structure-activity relationships". Curr. Med. Chem. 7 (2): 211–47. PMID 10637363. doi:10.2174/0929867003375371.
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