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|Systematic (IUPAC) name|
6,14-endoetheno – 7 a (1-(R)-hydroxy-1 methylbutyl)-tetrahydro-nororipavine
|AHFS/Drugs.com||International Drug Names|
|ATCvet code||QN02AE90 (WHO)|
|Molar mass||411.53 g/mol|
|(what is this?)|
Etorphine (M99) is a semi-synthetic opioid possessing an analgesic potency approximately 1,000–3,000 times that of morphine. It was first prepared in 1960 from oripavine, which does not generally occur in opium poppy extract but rather in "poppy straw" and in the related plants Papaver orientale and Papaver bracteatum. It was later reproduced in 1963 by a research group at MacFarlan Smith in Gorgie, Edinburgh, led by Professor Kenneth Bentley. It can also be produced from thebaine.
Etorphine is available legally only for veterinary use and is strictly governed by law. It is often used to immobilize elephants and other large mammals. Diprenorphine (M5050), also known as Revivon, is an opioid receptor antagonist that can be administered in proportion to the amount of etorphine used (1.3 times) to reverse its effects. Veterinary-strength etorphine is fatal to humans. For this reason the package as supplied to vets always includes the human antidote as well as etorphine. The human antidote is generally naloxone, not diprenorphine, and is always prepared before the preparation of etorphine to be immediately administered following accidental human exposure to etorphine. The LD50 in humans is 30 μg which lead to the requirement that the medicine include an equal dose of an antagonist, diprenorphine or naloxone.
One of its main advantages is its speed of operation and, more importantly, the speed with which diprenorphine reverses the effects. The high incidence of side-effects, including severe cardiopulmonary depression, has caused etorphine to fall into disfavor in general veterinary practice. However, its high potency combined with the rapid action of both etorphine and its antagonist, diprenorphine, means that it has found a place for capture of large mammals such as rhinoceroses and elephants; under these circumstances both rapid onset and rapid recovery are very important characteristics. The high potency of etorphine means that sufficient etorphine can be administered to large wild mammals by projectile syringe (dart).
Large Animal Immobilon is a combination of etorphine plus acepromazine maleate. An etorphine antidote Large Animal Revivon contains mainly diprenorphine for animals and a human-specific naloxone-based antidote, which should be prepared prior to the etorphine. A 5–15 mg dose is enough to immobilize an African elephant and a 2–4 mg dose is enough to immobilize a Black Rhino.
Etorphine is an extremely potent, non-selective full agonist of the μ-, δ-, and κ-opioid receptors. It also has relatively weak affinity for the nociceptin receptor. Etorphine has an LD50 of 30μg in humans. Its mu affinity is 0.024nM compared with nalorphine nM 0.559Nm and diprenorphine 0.072kI so the compound naloxone would need large doses as it battles for space on receptors. Diprenorphine Carfentanil has a Ki of 0.0000007.
In Hong Kong, etorphine is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. It can be used legally only by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. Anyone who supplies the substance without prescription can be fined $10,000 (HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time.
In the US, etorphine is listed as a Schedule I drug with an ACSCN of 9056, although its hydrochloride salt is classified as Schedule II with an ACSCN of 9059. For both, the 2013 annual aggregate manufacturing quota for both was zero so presumably veterinary supplies of the hydrochloride are imported from Germany and/or the UK.
In the UK, under the Misuse of Drugs Act 1971, etorphine is controlled as a Class A substance.
In Popular Culture
In the Showtime television series, Dexter, the lead character immobilizes his victims using etorphine.
In the TV show Lewis, season 6, episode 1, an assassin uses etorphine to kill two people.
In the TV show Scandal, season 2, Episode 7, Quinn asks Huck, a former spy, which drug is best for immobilizing people; he responds "etorphine".
In the TV show Bones, season 10, episode 13, etorphine is used on an ex-con before he escapes and gets blown up.
In the TV show The Vampire Diaries, season 5, episode 6, etorphine is used on Professor Wesley Maxfield to knock him out so Katherine and Caroline can get some answers about vampire test subjects.
In the novel, "The Viscious Vet: An Agatha Raisin Mystery", by Marion Chesney under the nom de plume M.C. Beaton, etorphine (Immobilon) is used to murder a vet.
- 6,14-Endoethenotetrahydrooripavine - the central nucleus of all 'bentley compound' opioids under which class etorphine falls
- Dihydroetorphine – a close analog of etorphine that has been used as an opioid painkiller for human usage in China
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