He received his doctorate in 1897 and afterwards was associated with the Hôtel-Dieu and Hôpital Saint-Louis. From 1919 until 1934, he worked at the Hôpital des Enfants-Malades in Paris. Pediatrician Jacques-Joseph Grancher (1843–1907) and surgeon Paul Georges Dieulafoy (1839–1911) were important influences to his career. He was also a student of pediatrician Antoine Bernard-Jean Marfan (1858–1942) and collaborated with dermatologist François Henri Hallopeau (1842–1919).
Apert's medical research primarily dealt with genetic diseases and congenital abnormalities. In 1906 he published a case report, titled De l'acrocéphalosyndactylie, documenting several individuals who had congenital malformations of the skull in conjunction with joined fingers. The condition came to be known as "Apert syndrome", a syndrome consisting of a triad of disorders, namely craniosynostosis, syndactyly and maxillary underdevelopment.
- Who Named It Apert's syndrome
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