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Available structures
PDB Ortholog search: PDBe RCSB
Aliases EEF2, EEF-2, EF-2, EF2, SCA26, eukaryotic translation elongation factor 2, Eukaryotic elongation factor 2
External IDs MGI: 95288 HomoloGene: 134867 GeneCards: EEF2
RNA expression pattern
PBB GE EEF2 200094 s at fs.png

PBB GE EEF2 204102 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 3.98 – 3.99 Mb Chr 10: 81.18 – 81.18 Mb
PubMed search [1] [2]
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Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene.[3][4][5]

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation.[5]

It is the target of diphtheria toxin (from Corynebacterium diphtheriae), and exotoxin A (from Pseudomonas aeruginosa).[6] The inactivation of EF-2 by toxins inhibits protein production in the host, causing symptoms due to loss of function in affected cells.


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Rapp G, Klaudiny J, Hagendorff G, Luck MR, Scheit KH (Mar 1990). "Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells". Biol Chem Hoppe Seyler. 370 (10): 1071–5. doi:10.1515/bchm3.1989.370.2.1071. PMID 2610926. 
  4. ^ Kaneda Y, Yoshida MC, Kohno K, Uchida T, Okada Y (Jul 1984). "Chromosomal assignment of the gene for human elongation factor 2". Proc Natl Acad Sci U S A. 81 (10): 3158–62. doi:10.1073/pnas.81.10.3158. PMC 345240Freely accessible. PMID 6427766. 
  5. ^ a b "Entrez Gene: EEF2 eukaryotic translation elongation factor 2". 
  6. ^ Jørgensen R, Merrill AR, Andersen GR (February 2006). "The life and death of translation elongation factor 2". Biochem. Soc. Trans. 34 (Pt 1): 1–6. doi:10.1042/BST20060001. PMID 16246167. 

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