In 2005 she starred in the TV series Maria Flordeluna, right after the ending of the series she did a follow up series in the ABS-CBN's rival network titled Kamandag aired on GMA Network starring Richard Gutierrez. Since then she became part of GMA Network's female lead actress and starred in the multiple series such All About Eve, the short lived Saturday Paranormal series E.S.P. and LaLola. In 2009, she went back to ABS-CBN to do the Primetime hit series The Wedding, and The Last Prince in 2010 and the successful afternoon series, Koreana. In 2011, she was part of the remake of Mula Sa Puso as her comeback to ABS-CBN where she played Selina Matias. On the 20th Anniversary of MMK, she's the #1 featured actress with the most number of episodes (32 episodes, as of 2014) and she was hailed "MMK Queen". In 2012, as her comeback as a contract artist she currently plays Olivia La Pena on the hit film remake turned TV series Mundo Man ay Magunaw which was originally portrayed by Susan Roces and will be Black Lily at the book two of Walang Hanggan.
In 2015,PEP.com reported that Valdez would returned in GMA Network to joined the hit television series The Half Sisters.