Euphorbia peplus

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Euphorbia peplus
E peplus.jpg
Scientific classification edit
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Rosids
Order: Malpighiales
Family: Euphorbiaceae
Genus: Euphorbia
E. peplus
Binomial name
Euphorbia peplus

Euphorbia peplus (petty spurge,[1][2] radium weed,[2] cancer weed,[2] or milkweed),[2] is a species of Euphorbia, native to most of Europe, northern Africa and western Asia, where it typically grows in cultivated arable land, gardens and other disturbed land.[1][3][4]

Outside of its native range it is very widely naturalised and often invasive, including in Australia, New Zealand, North America and other countries in temperate and sub-tropical regions.[1]


It is an annual plant growing to 5–30 cm (2–12 in) tall (most plants growing as weeds of cultivation tend towards the smaller end), with smooth hairless stems. The leaves are oval-acute, 1–3 cm (0.4–1.2 in) long, with a smooth margin. It has green flowers in three-rayed umbels. The glands, typical of the Euphorbiaceae, are kidney-shaped with long thin horns.[4]

Euphorbia peplus cyathium

Medicinal uses[edit]

The plant's sap is toxic to rapidly replicating human tissue, and has long been used as a traditional remedy for common skin lesions.[5] The active ingredient in the sap is a diterpene ester called ingenol mebutate.

A pharmaceutical-grade ingenol mebutate gel has approval from the US Food and Drug Administration for treatment of actinic keratosis.[5][6][7]

In Germany, recent studies have linked Euphorbia peplus with the virtual elimination of squamous cell skin cancer.[8]


  1. ^ a b c "Euphorbia peplus". Germplasm Resources Information Network (GRIN). Agricultural Research Service (ARS), United States Department of Agriculture (USDA). Retrieved 2 January 2018.
  2. ^ a b c d Hazel Dempster; Bronwen Keighery; Greg Keighery; Rod Randall; Bob Dixon; Bill Betts; Margo O'Byrne; Diane Matthews. "Euphorbia terracina Workshop Proceedings 2000" (PDF). Archived from the original (PDF) on 2009-10-25.
  3. ^ Flora Europaea: Euphorbia peplus
  4. ^ a b Blamey, M. & Grey-Wilson, C. (1989). Flora of Britain and Northern Europe. ISBN 0-340-40170-2
  5. ^ a b Siller G, Gebauer K, Welburn P, Katsamas J, Ogbourne SM (2009). "PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study". Australasian Journal of Dermatology. 50 (1): 16–22. doi:10.1111/j.1440-0960.2008.00497.x. PMID 19178487. S2CID 19308099.
  6. ^ Lebwohl, M, et al. "Ingenol Mebutate Gel for Actinic Keratosis." N Engl J Med 366;11, March 15, 2012.
  7. ^ "FDA Approves Picato® (ingenol mebutate) Gel, the First and Only Topical Actinic Keratosis (AK) Therapy With 2 or 3 Consecutive Days of Once-Daily Dosing". eMedicine. Yahoo! Finance. January 25, 2012. Archived from the original on February 10, 2012.
  8. ^ Braun, S.A.; Homey, B.; Gerber, P.A. (October 2014). "Erfolgreiche Behandlung eines Morbus Bowen mit Ingenolmebutat". Der Hautarzt (in German). 65 (10): 848–850. doi:10.1007/s00105-014-3509-5. ISSN 0017-8470. PMID 25217087.