Eva Nogales

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Eva Nogales
Alma materB.S., physics, Autonomous University of Madrid in 1988, Ph.D., University of Keele, 1992
OccupationBiophysicist, professor
EmployerUniversity of California, Berkeley, Howard Hughes Medical Institute, Synchrotron Radiation Source
Known forThe first to determine the atomic structure of tubulin by electron crystallography
Spouse(s)Howard Padmore
ChildrenTwo children
AwardsEarly Career Award, American Society for Cell Biology (2005)
Chabot Science Award for Excellence (2006)

Eva Nogales (b. Madrid, Spain) is a biophysicist at the Lawrence Berkeley National Laboratory. She is a faculty member in the Division of Biochemistry, Biophysics and Structural Biology of the Department of Molecular and Cell Biology at the University of California, Berkeley and a Howard Hughes Medical Institute investigator.

Eva Nogales works on structural and functional characterization of macromolecular complexes. Her lab uses electron microscopy, computational image analysis as well as functional biochemical assays to gain insights into function and regulation of the large biological assemblies. Her group used cryo-electron microscopy, a rising star in lab techniques.[1] Her work has uncovered aspects of cellular function that are relevant to the treatment of cancer and other diseases.[2]

Early life and education[edit]

Eva Nogales obtained her B.S. degree in physics from the Autonomous University of Madrid in 1988. She later earned her Ph.D. from the University of Keele in 1992 while working at the Synchrotron Radiation Source under the supervision of Joan Bordas.


During her post-doctoral work in the Ken Downing lab, Eva Nogales was the first to determine the atomic structure of tubulin by electron crystallography.[3]

She now continues to study microtubule dynamics in her own laboratory.[4] In addition to microtubules, Dr. Nogales explores the structural and functional aspects of large macromolecular assemblies such as eukaryotic transcription and translation initiation complexes.[5]

Nogales was selected for membership in the American Academy of Arts and Sciences, along with three other Berkeley Lab scientists, including Glaeser, who worked with Nogales on cryo-electron microscopy, a technology that uses an electron microscope to see protein molecules in atomic detail.[6]


Nogales is a recipient of several awards including Early Career Award by the American Society for Cell Biology (2005), and the Chabot Science Award for Excellence (2006). In April 2015, she was elected as a member of the US National Academy of Sciences, 2015.

Personal life[edit]

Nogales is married to Howard Padmore and they have two children.

  1. ^ "How to See Living Machines". Medical Design Technology. 2016-12-07. Retrieved 2018-02-03.
  2. ^ 4-traders. "4-Traders". www.4-traders.com. Retrieved 2018-02-03.
  3. ^ Nogales, E., Wolf, S. G. and Downing, K. H. (1998.) Structure of the ab tubulin dimer by electron crystallography. Nature, 391, 199-203.
  4. ^ Nogales, E., Wang. H-W. (2006.) Structural intermediates in microtubule assembly and disassembly: how and why? Curr. Opin. Cell. Biol., 18(2):179-84.
  5. ^ Michael A. Cianfrocco, George A. Kassavetis, Patricia Grob, Jie Fang, Tamar Juven-Gershon, James T. Kadonaga, Eva Nogales (2013.) Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State. Cell, 152(1):120-131.
  6. ^ "9 campus faculty selected for membership in American Academy of Arts and Sciences | The Daily Californian". The Daily Californian. 2016-04-22. Retrieved 2018-02-03.