He attended musical classes at the Cadet Corps, Tbilisi Real School and finally entered the Tbilisi National Conservatory. Since his childhood, he played various wind instruments, chiefly the trumpet and the French horn, and decided to become a conductor in the mid-1920s. He then took courses at the Leningrad State Conservatory under the guidance of eminent Soviet conductors, Nikolai Malko and Aleksandr Gauk. Back to Tbilisi in 1931, he quickly gained notability as a talented conductor and a promoter of classical music, and earned appraisal from several Soviet and foreign musicians. He organized and led, in 1933, the National Symphony Orchestra of Georgia. A year later, he became a chief conductor at the Tbilisi Opera House.
At the age of 33, he was awarded the title of Honored Artist of the Georgian SSR (1936). Mikeladze’s productive career was soon to be abruptly terminated, however. He was married to the daughter of Mamia Orakhelashvili, an Old Bolshevik who was purged under Stalin in 1937. Mikeladze was also arrested in November 1937 and subjected to forty-eight days of interrogation and torture, being allegedly questioned and beaten also by Lavrentiy Beria. Eventually, Mikeladze was sentenced to be shot by the NKVD troika.
In a newly independent post-Soviet Georgia, his name has been given to the National Symphony Orchestra founded and led by Mikeladze.
- "According to one account, Beria also questioned him. Although Mikeladze was blindfolded he recognized Beria, saying "You have covered my eyes, but my hearing is as good as ever." Beria then gave such a blow to the head that he was rendered deaf." Knight, p. 83.
- (Russian) Микеладзе, Вахтанг Евгеньевич