|Part of a series on|
Evidence-based medicine (EBM) is "the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients." The aim of EBM is to integrate the experience of the clinician, the values of the patient, and the best available scientific information to guide decision-making about clinical management. The term was originally used to describe an approach to teaching the practice of medicine and improving decisions by individual physicians about individual patients.
Background, history and definition
Let us take out of the Hospitals, out of the Camps, or from elsewhere, 200, or 500 poor People, that have fevers or Pleuritis. Let us divide them in Halfes, let us cast lots, that one halfe of them may fall to my share, and the others to yours; I will cure them without blood-letting and sensible evacuation; but you do, as ye know ... we shall see how many Funerals both of us shall have...
The first published report describing the conduct and results of a controlled clinical trial was by James Lind, a Scot Naval Surgeon who conducted research on scurvy during his time aboard HMS Salisbury in the Channel Fleet, while patrolling the Bay of Biscay. Lind divided the sailors participating in his experiment into six groups, so that the effects of various treatments could be fairly compared. Lind found improvement in symptoms and signs of scurvy among the group of men treated with lemons or oranges. He published a treatise describing the results of this experiment in 1753.
An early critique of statistical methods in medicine was published in 1835.
Clinical decision making
Alvan Feinstein's publication of Clinical Judgment in 1967 focused attention on the role of clinical reasoning and identified biases that can affect it. In 1972, Archie Cochrane published Effectiveness and Efficiency, which described the lack of controlled trials supporting many practices that had previously been assumed to be effective. In 1973, John Wennberg began to document wide variations in how physicians practiced. Through the 1980s, David M. Eddy described errors in clinical reasoning and gaps in evidence. In the mid 1980s, Alvin Feinstein, David Sackett and others published textbooks on clinical epidemiology, which translated epidemiological methods to physician decision making. Toward the end of the 1980s, a group at RAND showed that large proportions of procedures performed by physicians were considered inappropriate even by the standards of their own experts.
Evidence-based guidelines and policies
David M. Eddy first began to use the term "evidence-based" in 1987 in workshops and a manual commissioned by the Council of Medical Specialty Societies to teach formal methods for designing clinical practice guidelines. The manual was eventually published by the American College of Physicians. Eddy first published the term "evidence-based" in March, 1990, in an article in the Journal of the American Medical Association that laid out the principles of evidence-based guidelines and population-level policies, which Eddy described as "explicitly describing the available evidence that pertains to a policy and tying the policy to evidence instead of standard-of-care practices or the beliefs of experts. The pertinent evidence must be identified, described, and analyzed. The policymakers must determine whether the policy is justified by the evidence. A rationale must be written." He discussed "evidence-based" policies in several other papers published in JAMA in the spring of 1990. Those papers were part of a series of 28 published in JAMA between 1990 and 1997 on formal methods for designing population-level guidelines and policies.
The term "evidence-based medicine" was introduced slightly later, in the context of medical education. In the autumn of 1990, Gordon Guyatt used it in an unpublished description of a program at McMaster University for prospective or new medical students. Guyatt and others first published the term two years later (1992) to describe a new approach to teaching the practice of medicine.
In 1996, David Sackett and colleagues clarified the definition of this tributary of evidence-based medicine as "the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. ... [It] means integrating individual clinical expertise with the best available external clinical evidence from systematic research." This branch of evidence-based medicine aims to make individual decision making more structured and objective by better reflecting the evidence from research. Population-based data are applied to the care of an individual patient, while respecting the fact that practitioners have clinical expertise reflected in effective and efficient diagnosis and thoughtful identification and compassionate use of individual patients' predicaments, rights, and preferences.
Between 1993 and 2000, the Evidence-based Medicine Working Group at McMaster University published the methods to a broad physician audience in a series of 25 "Users' Guides to the Medical Literature" in JAMA. In 1995 Rosenberg and Donald defined individual level evidence-based medicine as "the process of finding, appraising, and using contemporaneous research findings as the basis for medical decisions." In 2010, Greenhalgh used a definition that emphasized quantitative methods: "the use of mathematical estimates of the risk of benefit and harm, derived from high-quality research on population samples, to inform clinical decision-making in the diagnosis, investigation or management of individual patients."
The two original definitions[which?] highlight important differences in how evidence-based medicine is applied to populations versus individuals. When designing guidelines applied to large groups of people in settings where there is relatively little opportunity for modification by individual physicians, evidence-based policymaking stresses that there should be good evidence to document a test's or treatment's effectiveness. In the setting of individual decision-making, practitioners can be given greater latitude in how they interpret research and combine it with their clinical judgment. In 2005, Eddy offered an umbrella definition for the two branches of EBM: "Evidence-based medicine is a set of principles and methods intended to ensure that to the greatest extent possible, medical decisions, guidelines, and other types of policies are based on and consistent with good evidence of effectiveness and benefit."
On the evidence-based guidelines and policies side, explicit insistence on evidence of effectiveness was introduced by the American Cancer Society in 1980. The U.S. Preventive Services Task Force (USPSTF) began issuing guidelines for preventive interventions based on evidence-based principles in 1984. In 1985, the Blue Cross Blue Shield Association applied strict evidence-based criteria for covering new technologies. Beginning in 1987, specialty societies such as the American College of Physicians, and voluntary health organizations such as the American Heart Association, wrote many evidence-based guidelines. In 1991, Kaiser Permanente, a managed care organization in the US, began an evidence-based guidelines program. In 1991, Richard Smith wrote an editorial in the British Medical Journal and introduced the ideas of evidence-based policies in the UK. In 1993, the Cochrane Collaboration created a network of 13 countries to produce systematic reviews and guidelines. In 1997, the US Agency for Healthcare Research and Quality (AHRQ, then known as the Agency for Health Care Policy and Research, or AHCPR) established Evidence-based Practice Centers (EPCs) to produce evidence reports and technology assessments to support the development of guidelines. In the same year, a National Guideline Clearinghouse that followed the principles of evidence-based policies was created by AHRQ, the AMA, and the American Association of Health Plans (now America's Health Insurance Plans). In 1999, the National Institute for Clinical Excellence (NICE) was created in the UK.
On the medical education side, programs to teach evidence-based medicine have been created in medical schools in Canada, the US, the UK, Australia, and other countries. A 2009 study of UK programs found the more than half of UK medical schools offered some training in evidence-based medicine, although there was considerable variation in the methods and content, and EBM teaching was restricted by lack of curriculum time, trained tutors and teaching materials. Many programs have been developed to help individual physicians gain better access to evidence. For example, UpToDate was created in the early 1990s. The Cochrane Collaboration began publishing evidence reviews in 1993. BMJ Publishing Group launched a 6-monthly periodical in 1995 called Clinical Evidence that provided brief summaries of the current state of evidence about important clinical questions for clinicians.
By 2000, "evidence-based medicine" had become an umbrella term for the emphasis on evidence in both population-level and individual-level decisions. In subsequent years, use of the term "evidence-based" had extended to other levels of the health care system. An example is "evidence-based health services", which seek to increase the competence of health service decision makers and the practice of evidence-based medicine at the organizational or institutional level.
The multiple tributaries of evidence-based medicine share an emphasis on the importance of incorporating evidence from formal research in medical policies and decisions. However, they differ on the extent to which they require good evidence of effectiveness before promoting a guideline or payment policy; hence, the distinction sometimes made between evidence-based medicine and science-based medicine, which also takes into account factors, such as prior plausibility and compatibility with established science as when medical organizations promote controversial treatments such as acupuncture. They also differ on the extent to which it is feasible to incorporate individual-level information in decisions. Thus, evidence-based guidelines and policies may not readily 'hybridise' with experience-based practices orientated towards ethical clinical judgement, and can lead to contradictions, contest, and unintended crises. The most effective 'knowledge leaders' (managers and clinical leaders) use a broad range of management knowledge in their decision making, rather than just formal evidence. Evidence-based guidelines may provide the basis for governmentality in health care, and consequently play a central role in the governance of contemporary health care systems.
The steps for designing explicit, evidence-based guidelines were described in the late 1980s: Formulate the question (population, intervention, comparison intervention, outcomes, time horizon, setting); search the literature to identify studies that inform the question; interpret each study to determine precisely what it says about the question; if several studies address the question, synthesize their results (meta-analysis); summarize the evidence in "evidence tables"; compare the benefits, harms and costs in a "balance sheet"; draw a conclusion about the preferred practice; write the guideline; write the rationale for the guideline; have others review each of the previous steps; implement the guideline.
For the purposes of medical education and individual-level decision making, five steps of EBM in practice were described in 1992 and the experience of delegates attending the 2003 Conference of Evidence-Based Health Care Teachers and Developers was summarized into five steps and published in 2005. This five step process can broadly be categorized as:
- Translation of uncertainty to an answerable question and includes critical questioning, study design and levels of evidence
- Systematic retrieval of the best evidence available
- Critical appraisal of evidence for internal validity that can be broken down into aspects regarding:
- Systematic errors as a result of selection bias, information bias and confounding
- Quantitative aspects of diagnosis and treatment
- The effect size and aspects regarding its precision
- Clinical importance of results
- External validity or generalizability
- Application of results in practice
- Evaluation of performance
Systematic reviews of published research studies are a major part of the evaluation of particular treatments. The Cochrane Collaboration is one of the best-known organisations that conducts systematic reviews. Like other producers of systematic reviews, it requires authors to provide a detailed and repeatable plan of their literature search and evaluations of the evidence. Once all the best evidence is assessed, treatment is categorized as (1) likely to be beneficial, (2) likely to be harmful, or (3) evidence did not support either benefit or harm.
A 2007 analysis of 1,016 systematic reviews from all 50 Cochrane Collaboration Review Groups found that 44% of the reviews concluded that the intervention was likely to be beneficial, 7% concluded that the intervention was likely to be harmful, and 49% concluded that evidence did not support either benefit or harm. 96% recommended further research. In 2017, a study assessed the role of systematic reviews produced by Cochrane Collaboration to inform US private payers' policies making; it showed that though medical policy documents of major US private payers were informed by Cochrane systematic reviews there was still scope to encourage the further usage.
Assessing the quality of evidence
Evidence-based medicine categorizes different types of clinical evidence and rates or grades them according to the strength of their freedom from the various biases that beset medical research. For example, the strongest evidence for therapeutic interventions is provided by systematic review of randomized, well-blinded, placebo-controlled trials with allocation concealment and complete follow-up involving a homogeneous patient population and medical condition. In contrast, patient testimonials, case reports, and even expert opinion (however, some critics have argued that expert opinion "does not belong in the rankings of the quality of empirical evidence because it does not represent a form of empirical evidence" and continue that "expert opinion would seem to be a separate, complex type of knowledge that would not fit into hierarchies otherwise limited to empirical evidence alone") have little value as proof because of the placebo effect, the biases inherent in observation and reporting of cases, difficulties in ascertaining who is an expert and more.
Several organizations have developed grading systems for assessing the quality of evidence. For example, in 1989 the U.S. Preventive Services Task Force (USPSTF) put forth the following:
- Level I: Evidence obtained from at least one properly designed randomized controlled trial.
- Level II-1: Evidence obtained from well-designed controlled trials without randomization.
- Level II-2: Evidence obtained from well-designed cohort studies or case-control studies, preferably from more than one center or research group.
- Level II-3: Evidence obtained from multiple time series designs with or without the intervention. Dramatic results in uncontrolled trials might also be regarded as this type of evidence.
- Level III: Opinions of respected authorities, based on clinical experience, descriptive studies, or reports of expert committees.
Another example is the Oxford (UK) CEBM Levels of Evidence. First released in September 2000, the Oxford CEBM Levels of Evidence provides 'levels' of evidence for claims about prognosis, diagnosis, treatment benefits, treatment harms, and screening, which most grading schemes do not address. The original CEBM Levels was Evidence-Based On Call to make the process of finding evidence feasible and its results explicit. In 2011, an international team redesigned the Oxford CEBM Levels to make it more understandable and to take into account recent developments in evidence ranking schemes. The Oxford CEBM Levels of Evidence have been used by patients, clinicians and also to develop clinical guidelines including recommendations for the optimal use of phototherapy and topical therapy in psoriasis and guidelines for the use of the BCLC staging system for diagnosing and monitoring hepatocellular carcinoma in Canada.
In 2000, a system was developed by the GRADE (short for Grading of Recommendations Assessment, Development and Evaluation) working group and takes into account more dimensions than just the quality of medical research. It requires users of GRADE who are performing an assessment of the quality of evidence, usually as part of a systematic review, to consider the impact of different factors on their confidence in the results. Authors of GRADE tables grade the quality of evidence into four levels, on the basis of their confidence in the observed effect (a numerical value) being close to what the true effect is. The confidence value is based on judgements assigned in five different domains in a structured manner. The GRADE working group defines 'quality of evidence' and 'strength of recommendations' based on the quality as two different concepts which are commonly confused with each other.
Systematic reviews may include randomized controlled trials that have low risk of bias, or, observational studies that have high risk of bias. In the case of randomized controlled trials, the quality of evidence is high, but can be downgraded in five different domains.
- Risk of bias: Is a judgement made on the basis of the chance that bias in included studies has influenced the estimate of effect.
- Imprecision: Is a judgement made on the basis of the chance that the observed estimate of effect could change completely.
- Indirectness: Is a judgement made on the basis of the differences in characteristics of how the study was conducted and how the results are actually going to be applied.
- Inconsistency: Is a judgement made on the basis of the variability of results across the included studies.
- Publication bias: Is a judgement made on the basis of the question whether all the research evidence has been taken to account.
In the case of observational studies per GRADE, the quality of evidence starts of lower and may be upgraded in three domains in addition to being subject to downgrading.
- Large effect: This is when methodologically strong studies show that the observed effect is so large that the probability of it changing completely is less likely.
- Plausible confounding would change the effect: This is when despite the presence of a possible confounding factor which is expected to reduce the observed effect, the effect estimate still shows significant effect.
- Dose response gradient: This is when the intervention used becomes more effective with increasing dose. This suggests that a further increase will likely bring about more effect.
Meaning of the levels of quality of evidence as per GRADE:
- High Quality Evidence: The authors are very confident that the estimate that is presented lies very close to the true value. One could interpret it as "there is very low probability of further research completely changing the presented conclusions."
- Moderate Quality Evidence: The authors are confident that the presented estimate lies close to the true value, but it is also possible that it may be substantially different. One could also interpret it as: further research may completely change the conclusions.
- Low Quality Evidence: The authors are not confident in the effect estimate and the true value may be substantially different. One could interpret it as "further research is likely to change the presented conclusions completely."
- Very low quality Evidence: The authors do not have any confidence in the estimate and it is likely that the true value is substantially different from it. One could interpret it as "new research will most probably change the presented conclusions completely."
Categories of recommendations
In guidelines and other publications, recommendation for a clinical service is classified by the balance of risk versus benefit and the level of evidence on which this information is based. The U.S. Preventive Services Task Force uses:
- Level A: Good scientific evidence suggests that the benefits of the clinical service substantially outweigh the potential risks. Clinicians should discuss the service with eligible patients.
- Level B: At least fair scientific evidence suggests that the benefits of the clinical service outweighs the potential risks. Clinicians should discuss the service with eligible patients.
- Level C: At least fair scientific evidence suggests that there are benefits provided by the clinical service, but the balance between benefits and risks are too close for making general recommendations. Clinicians need not offer it unless there are individual considerations.
- Level D: At least fair scientific evidence suggests that the risks of the clinical service outweighs potential benefits. Clinicians should not routinely offer the service to asymptomatic patients.
- Level I: Scientific evidence is lacking, of poor quality, or conflicting, such that the risk versus benefit balance cannot be assessed. Clinicians should help patients understand the uncertainty surrounding the clinical service.
GRADE guideline panelists may make strong or weak recommendations on the basis of further criteria. Some of the important criteria are the balance between desirable and undesirable effects (not considering cost), the quality of the evidence, values and preferences and costs (resource utilization).
Despite the differences between systems, the purposes are the same: to guide users of clinical research information on which studies are likely to be most valid. However, the individual studies still require careful critical appraisal.
Evidence-based medicine attempts to express clinical benefits of tests and treatments using mathematical methods. Tools used by practitioners of evidence-based medicine include:
- Likelihood ratio pre-test odds of a particular diagnosis, multiplied by the likelihood ratio, determines the post-test odds. (Odds can be calculated from, and then converted to, the [more familiar] probability.) This reflects Bayes' theorem. The differences in likelihood ratio between clinical tests can be used to prioritize clinical tests according to their usefulness in a given clinical situation. The
- AUC-ROC The area under the receiver operating characteristic curve (AUC-ROC) reflects the relationship between sensitivity and specificity for a given test. High-quality tests will have an AUC-ROC approaching 1, and high-quality publications about clinical tests will provide information about the AUC-ROC. Cutoff values for positive and negative tests can influence specificity and sensitivity, but they do not affect AUC-ROC.
- Number needed to treat (NNT)/Number needed to harm (NNH). Number needed to treat or number needed to harm are ways of expressing the effectiveness and safety, respectively, of interventions in a way that is clinically meaningful. NNT is the number of people who need to be treated in order to achieve the desired outcome (e.g. survival from cancer) in one patient. For example, if a treatment increases the chance of survival by 5%, then 20 people need to be treated in order to have 1 additional patient survive due to the treatment. The concept can also be applied to diagnostic tests. For example, if 1,339 women age 50–59 have to be invited for breast cancer screening over a ten-year period in order to prevent one woman from dying of breast cancer, then the NNT for being invited to breast cancer screening is 1339.
Quality of clinical trials
This section does not cite any sources. (June 2017) (Learn how and when to remove this template message)
Evidence-based medicine attempts to objectively evaluate the quality of clinical research by critically assessing techniques reported by researchers in their publications.
- Trial design considerations. High-quality studies have clearly defined eligibility criteria and have minimal missing data.
- Generalizability considerations. Studies may only be applicable to narrowly defined patient populations and may not be generalizable to other clinical contexts.
- Follow-up. Sufficient time for defined outcomes to occur can influence the prospective study outcomes and the statistical power of a study to detect differences between a treatment and control arm.
- Power. A mathematical calculation can determine if the number of patients is sufficient to detect a difference between treatment arms. A negative study may reflect a lack of benefit, or simply a lack of sufficient quantities of patients to detect a difference.
Limitations and criticism
There are a number of limitations and criticisms of evidence-based medicine. Two widely cited categorization schemes for the various published critiques of EBM include the three-fold division of Straus and McAlister ("limitations universal to the practice of medicine, limitations unique to evidence-based medicine and misperceptions of evidence-based-medicine") and the five-point categorization of Cohen, Stavri and Hersh (EBM is a poor philosophic basis for medicine, defines evidence too narrowly, is not evidence-based, is limited in usefulness when applied to individual patients, or reduces the autonomy of the doctor/patient relationship).
In no particular order, some published objections include:
- The theoretical ideal of EBM (that every narrow clinical question, of which hundreds of thousands can exist, would be answered by meta-analysis and systematic reviews of multiple RCTs) faces the limitation that research (especially the RCTs themselves) is expensive; thus, in reality, for the foreseeable future, there will always be much more demand for EBM than supply, and the best humanity can do is to triage the application of scarce resources.
- Research produced by EBM, such as from randomized controlled trials (RCTs), may not be relevant for all treatment situations. Research tends to focus on specific populations, but individual persons can vary substantially from population norms. Since certain population segments have been historically under-researched (racial minorities and people with co-morbid diseases), evidence from RCTs may not be generalizable to those populations. Thus EBM applies to groups of people, but this should not preclude clinicians from using their personal experience in deciding how to treat each patient. One author advises that "the knowledge gained from clinical research does not directly answer the primary clinical question of what is best for the patient at hand" and suggests that evidence-based medicine should not discount the value of clinical experience. Another author stated that "the practice of evidence-based medicine means integrating individual clinical expertise with the best available external clinical evidence from systematic research."
- Research can be influenced by biases such as publication bias and conflict of interest in academic publishing. For example, studies with conflicts due to industry funding are more likely to favor their product.
- There is a lag between when the RCT is conducted and when its results are published.
- There is a lag between when results are published and when these are properly applied.
- Hypocognition (the absence of a simple, consolidated mental framework that new information can be placed into) can hinder the application of EBM.
- Values: while patient values are considered in the original definition of EBM, the importance of values is not commonly emphasized in EBM training, a potential problem under current study.
A 2018 study, "Why all randomised controlled trials produce biased results", assessed the 10 most cited RCTs and argued that trials face a wide range of biases and constraints, from trials only being feasible to study a small set of questions amenable to randomisation and generally only being able to assess the average treatment effect of a sample, to limitations in extrapolating results to another context, among many others outlined in the study.
Application of evidence in clinical settings
Despite the emphasis on evidence-based medicine, unsafe or ineffective medical practices continue to be applied, because of patient demand for tests or treatments, because of failure to access information about the evidence, or because of the rapid pace of change in the scientific evidence. For example, between 2003 and 2017, the evidence shifted on hundreds of medical practices, ranging from whether hormone replacement therapy was safe to whether babies should be given certain vitamins to whether antidepressant drugs are effective in people with Alzheimer's disease. Even when the evidence is unequivocally against a treatment, it usually takes ten years for other treatments to be adopted. In other cases, significant change can require a generation of physicians to retire or die, and be replaced by physicians who were trained with more recent evidence.
Physicians may also reject evidence which conflicts with their anecdotal experience or because of cognitive biases – for example, a vivid memory of a rare but shocking outcome (the availability heuristic), such as a patient dying after refusing treatment. They may overtreat to "do something" or to address a patient's emotional needs. They may worry about malpractice charges based on a discrepancy between what the patient expects and what the evidence recommends. They may also overtreat or provide ineffective treatments because the treatment feels biologically plausible.
Training in evidence based medicine is offered across the continuum of medical education.
The Berlin questionnaire and the Fresno Test are validated instruments for assessing the effectiveness of education in evidence-based medicine. These questionnaires have been used in diverse settings.
A Campbell systematic review that included 24 trials examined the effectiveness of e-learning in improving evidence-based health care knowledge and practice. It was found that e-learning, compared to no learning, improves evidence-based health care knowledge and skills but not attitudes and behaviour. There is no difference in outcomes when comparing e-learning to face-to-face learning. Combining e-learning with face-to-face learning (blended learning) has a positive impact on evidence-based knowledge, skills, attitude and behaviour. Related to e-learning, medical school students have engaged with editing Wikipedia to increase their EBM skills.
- Anecdotal evidence
- Clinical decision support system (CDSS)
- Clinical epidemiology
- Consensus (medical)
- Evidence-based dentistry
- Evidence-based design
- Evidence-based nursing
- Evidence-based policy
- Evidence-based practices
- Evidence-based management
- Evidence-based research (Metascience)
- Medical algorithm
- Paradigm shift – the social process by which scientific evidence is eventually adopted
- Personalized medicine
- Policy-based evidence making
- Precision medicine
- Sackett DL, Rosenberg WM, Gray JA, Haynes RB, Richardson WS (1996). "Evidence based medicine: what it is and what it isn't". BMJ. 312 (7023): 71–72. doi:10.1136/bmj.312.7023.71. PMC 2349778. PMID 8555924.
- Evidence-Based Medicine Working Group (November 1992). "Evidence-based medicine. A new approach to teaching the practice of medicine". JAMA. 268 (17): 2420–25. CiteSeerX 10.1.1.684.3783. doi:10.1001/JAMA.1992.03490170092032. PMID 1404801.
- Brater DC, Daly WJ (May 2000). "Clinical pharmacology in the Middle Ages: principles that presage the 21st century". Clin. Pharmacol. Ther. 67 (5): 447–50 See p. 449. doi:10.1067/mcp.2000.106465. PMID 10824622.
- Daly WJ, Brater DC (2000). "Medieval contributions to the search for truth in clinical medicine". Perspect. Biol. Med. 43 (4): 530–40 See p. 536. doi:10.1353/pbm.2000.0037. PMID 11058989. S2CID 30485275.
- John Baptista Van Helmont; John Chandler (translator) (1662). Oriatrike, or Physick Refined (English translation of Ortus medicinae).
- Lind, James (2018). Treatise on the scurvy. in three parts. ... by james lind ... the second edition corrected, ... with additions and improvements. Place of publication not identified: GALE ECCO, PRINT EDITIONS. ISBN 978-1-379-46980-3.
- Poisson, Dulong; Larrey, Double (2001) . "Statistical research on conditions caused by calculi by Doctor Civiale". Int J Epidemiol. 30 (6): 1246–49. doi:10.1093/ije/30.6.1246. PMID 11821317. Archived from the original on 2005-04-29.
- Guyatt GH. Evidence-Based Medicine [editorial]. ACP Journal Club 1991:A-16. (Annals of Internal Medicine; vol. 114, suppl. 2).
- "Development of evidence-based medicine explored in oral history video, AMA, JAN 27, 2014".
- Sackett DL, Rosenberg WM (November 1995). "The need for evidence-based medicine". J R Soc Med. 88 (11): 620–4. PMC 1295384. PMID 8544145.
- InformedHealth.org [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. The history of evidence-based medicine. 2016 Jun 15 [Updated 2016 Sep 8]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK390299/
- Alvan R. Feinstein (1967). Clinical Judgement. Williams & Wilkins.
- Cochrane A.L. (1972). Effectiveness and Efficiency: Random Reflections on Health Services. Nuffield Provincial Hospitals Trust.
- Wennberg J.E.; Gittelsohn A. (1973). "Small Area Variations in Health Care Delivery". Science. 182 (4117): 1102–08. Bibcode:1973Sci...182.1102W. doi:10.1126/science.182.4117.1102. PMID 4750608. S2CID 43819003.
- Eddy, David M. (1982). "18 Probabilistic Reasoning in Clinical Medicine: Problems and Opportunities". In Kahneman, D.; Slovic, P.; Tversky, A. (eds.). Judgment Under Uncertainty: Heuristics and Biases. Cambridge University Press. pp. 249–67. ISBN 978-0-521-28414-1.
- Eddy DM (1982). "Clinical Policies and the Quality of Clinical Practice". New England Journal of Medicine. 307 (6): 343–47. doi:10.1056/nejm198208053070604. PMID 7088099.
- Eddy DM (1984). "Variations in Physician Practice The Role of Uncertainty". Health Affairs. 3 (2): 74–89. doi:10.1377/hlthaff.3.2.74. PMID 6469198.
- Eddy DM (1988). "The Quality of Medical Evidence: Implications for Quality of Care". Health Affairs. 7 (1): 19–32. doi:10.1377/hlthaff.7.1.19. PMID 3360391.
- Feinstein AR (1985). Clinical Epidemiology: The Architecture of Clinical Research. ISBN 978-0-7216-1308-6.
- Sackett, Dave (2006). Haynes, R. Brian (ed.). Clinical Epidemiology: How to Do Clinical Practice Research. Lippincott Williams & Wilkins. ISBN 978-0-7817-4524-6.
- Chassin MR, Kosecoff J, Solomon DH, Brook RH (1987). "How Coronary Angiography Is Used: Clinical Determinants of Appropriateness". JAMA. 258 (18): 2543–47. doi:10.1001/jama.258.18.2543. PMID 3312657.
- Eddy DM (1992). A Manual for Assessing Health Practices and Designing Practice Policies. American College of Physicians. ISBN 978-0-943126-18-0.
- Institute of Medicine (1990). Field, M.J.; Lohr, K.N. (eds.). Clinical Practice Guidelines: Directions for a New Program. Washington, DC: National Academy of Sciences Press. p. 32. doi:10.17226/1626. ISBN 978-0-309-07666-1. PMC 5310095. PMID 25144032.
- Eddy DM (1990). "Practice Policies: Guidelines for Methods". JAMA. 263 (13): 1839–41. doi:10.1001/jama.263.13.1839. PMID 2313855.
- Eddy DM (1990). "Guidelines for Policy Statements". Journal of the American Medical Association. 263 (16): 2239–43. doi:10.1001/jama.1990.03440160101046. PMID 2319689.
- Eddy DM (1996). Clinical Decision Making: From Theory to Practice. A Collection of Essays. American Medical Association. ISBN 978-0-7637-0143-7.
- Howick, Jeremy H. (2011-02-23). The Philosophy of Evidence-based Medicine. Wiley. p. 15. ISBN 978-1-4443-4266-6.
- Katz, David L. (2001). Clinical Epidemiology & Evidence-Based Medicine: Fundamental Principles of Clinical Reasoning & Research. SAGE. ISBN 978-0-7619-1939-1.
- Grobbee, D.E.; Hoes, Arno W. (2009). Clinical Epidemiology: Principles, Methods, and Applications for Clinical Research. Jones & Bartlett Learning. ISBN 978-0-7637-5315-3.
- Doi, S.A.R. (2012). Understanding Evidence in Health Care: Using Clinical Epidemiology. South Yarra, VIC, Australia: Palgrave Macmillan. ISBN 978-1-4202-5669-7.
- Rosenberg W, Donald A (1995). "Evidence-based Medicine: An approach to Clinical Problem Solving". BMJ. 310 (6987): 1122–26. doi:10.1136/bmj.310.6987.1122. PMC 2549505. PMID 7742682.
- Greenhalgh, Trisha (2010). How to Read a Paper: The Basics of Evidence-Based Medicine (4th ed.). John Wiley & Sons. p. 1. ISBN 978-1-4443-9036-0.
- Eddy DM (1990). "Practice Policies – Where Do They Come from?". Journal of the American Medical Association. 263 (9): 1265, 1269, 1272, 1275. doi:10.1001/jama.263.9.1265. PMID 2304243.
- Greenhalgh, Trisha (December 2001). "The limits of evidence-based medicine". Respiratory Care. 46 (12): 1435–40. PMID 11728302.
- Eddy, DM (2005). "Evidence-based Medicine: a Unified Approach". Health Affairs. 24 (1): 9–17. doi:10.1377/hlthaff.24.1.9. PMID 15647211.
- Eddy DM (1980). "ACS report on the cancer-related health checkup". CA Cancer J Clin. 30 (4): 193–240. doi:10.3322/canjclin.30.4.194. PMID 6774802.
- "About the USPSTF". Archived from the original on August 15, 2014. Retrieved August 21, 2014.
- Rettig, R.A.; Jacobson, P.D.; Farquhar, C.M.; Aubry, W.M. (2007). False Hope: Bone Marrow Transplantation for Breast Cancer: Bone Marrow Transplantation for Breast Cancer. Oxford University Press. p. 183. ISBN 978-0-19-974824-2.
- Davino-Ramaya C, Krause LK, Robbins CW, Harris JS, Koster M, Chan W, Tom GI (2012). "Transparency matters: Kaiser Permanente's National Guideline Program methodological processes". Perm J. 16 (1): 55–62. doi:10.7812/tpp/11-134. PMC 3327114. PMID 22529761.
- Smith RJ (1991). "Where's the Wisdom: The Poverty of Medical Evidence". BMJ. 303 (6806): 798–99. doi:10.1136/bmj.303.6806.798. PMC 1671173. PMID 1932964.
- "The Cochrane Collaboration". Retrieved August 21, 2014.
- "Agency for Health Care Policy and Research". Retrieved August 21, 2014.
- "National Guideline Clearinghouse". Archived from the original on August 19, 2014. Retrieved August 21, 2014.
- "National Institute for Health and Care Excellence". Retrieved August 21, 2014.
- Ilic, D; Maloney, S (February 2014). "Methods of teaching medical trainees evidence-based medicine: a systematic review". Medical Education. 48 (2): 124–35. doi:10.1111/medu.12288. PMID 24528395.
- Maggio, LA; Tannery, NH; Chen, HC; ten Cate, O; O'Brien, B (July 2013). "Evidence-based medicine training in undergraduate medical education: a review and critique of the literature published 2006–2011". Academic Medicine. 88 (7): 1022–8. doi:10.1097/ACM.0b013e3182951959. PMID 23702528.
- Meats E, Heneghan C, Crilly M, Glasziou P (April 2009). "Evidence-based medicine teaching in UK medical schools". Med Teach. 31 (4): 332–37. doi:10.1080/01421590802572791. PMID 19404893. S2CID 21133182.
- "UpToDate". Retrieved August 21, 2014.
- "Clinical Evidence". Retrieved August 21, 2014.
- Gray, J. A. Muir (2009). Evidence-based Health Care & Public Health. Churchill Livingstone. ISBN 978-0-443-10123-6.
- "AAFP promotes acupuncture". Science-Based Medicine. 9 October 2018. Retrieved 12 January 2019.
- Cook DJ, Jaeschke R, Guyatt GH (1992). "Critical appraisal of therapeutic interventions in the intensive care unit: human monoclonal antibody treatment in sepsis. Journal Club of the Hamilton Regional Critical Care Group". J Intensive Care Med. 7 (6): 275–82. doi:10.1177/088506669200700601. PMID 10147956. S2CID 7194293.
- Dawes M, Summerskill W, Glasziou P, et al. (January 2005). "Sicily statement on evidence-based practice". BMC Med Educ. 5 (1): 1. doi:10.1186/1472-6920-5-1. PMC 544887. PMID 15634359.
- Richardson WS, Wilson MC, Nishikawa J, Hayward RS (1995). "The well-built clinical question: a key to evidence-based decisions". ACP J. Club. 123 (3): A12–13. PMID 7582737.
- Rosenberg WM, Deeks J, Lusher A, Snowball R, Dooley G, Sackett D (1998). "Improving searching skills and evidence retrieval". J R Coll Physicians Lond. 32 (6): 557–63. PMID 9881313.
- Doi, S.A.R. (2012). Understanding Evidence in Health Care: Using Clinical Epidemiology. South Yarra, VIC, Australia: Palgrave Macmillan. ISBN 978-1-4202-5669-7.
- Epling J, Smucny J, Patil A, Tudiver F (October 2002). "Teaching evidence-based medicine skills through a residency-developed guideline". Fam Med. 34 (9): 646–48. PMID 12455246.
- Ivers, N; Jamtvedt, G; Flottorp, S; Young, JM; Odgaard-Jensen, J; French, SD; O'Brien, MA; Johansen, M; Grimshaw, J; Oxman, AD (13 June 2012). "Audit and feedback: effects on professional practice and healthcare outcomes". The Cochrane Database of Systematic Reviews. 6 (6): CD000259. doi:10.1002/14651858.CD000259.pub3. PMID 22696318.
- Tanjong-Ghogomu, E; Tugwell, P; Welch, V (2009). "Evidence-based medicine and the Cochrane Collaboration". Bulletin of the NYU Hospital for Joint Diseases. 67 (2): 198–205. PMID 19583554. Archived from the original on 2013-06-01.
- El Dib RP, Atallah AN, Andriolo RB (August 2007). "Mapping the Cochrane evidence for decision making in health care". J Eval Clin Pract. 13 (4): 689–92. doi:10.1111/j.1365-2753.2007.00886.x. PMID 17683315.
- Singh A, Hussain S, Najmi AK (2017). "Role of Cochrane Reviews in informing US private payers' policies". J Evid Based Med. 10 (4): 293–331. doi:10.1111/jebm.12278. PMID 29193899. S2CID 22796658.
- "EBM: Levels of Evidence". Essential Evidence Plus. Retrieved 2012-02-23.
- Tonelli MR (November 1999). "In defense of expert opinion". Acad Med. 74 (11): 1187–92. doi:10.1097/00001888-199911000-00010. PMID 10587679.
- U.S. Preventive Services Task Force (August 1989). Guide to clinical preventive services: report of the U.S. Preventive Services Task Force. DIANE Publishing. pp. 24–. ISBN 978-1-56806-297-6.
- OCEBM Levels of Evidence Working Group (May 2016). "The Oxford Levels of Evidence 2'".
- Paul, C.; Gallini, A.; Archier, E.; et al. (2012). "Evidence-Based Recommendations on Topical Treatment and Phototherapy of Psoriasis: Systematic Review and Expert Opinion of a Panel of Dermatologists". Journal of the European Academy of Dermatology and Venereology. 26 (Suppl 3): 1–10. doi:10.1111/j.1468-3083.2012.04518.x. PMID 22512675.
- "Welcome to the GRADE working group". www.gradeworkinggroup.org. Archived from the original on 2006-02-07. Retrieved 2007-09-24.
- Balshem H, Helfand M, Schünemann HJ, et al. (April 2011). "GRADE guidelines: 3. Rating the quality of evidence". J Clin Epidemiol. 64 (4): 401–6. doi:10.1016/j.jclinepi.2010.07.015. PMID 21208779.
- Schünemann H, Brożek J, Oxman A, eds. (2009). GRADE handbook for grading quality of evidence and strength of recommendation (Version 3.2 ed.).
"GRADEPro". Cochrane Informatics and Knowledge Management Department. Archived from the original on 2016-03-05. Retrieved 2016-03-01.
Schünemann H, Brożek J, Guyatt G, Oxman A, eds. (2013). GRADE handbook for grading quality of evidence and strength of recommendations. Updated October 2013. The GRADE Working Group. Retrieved 2019-09-03.
- Sherman, M; Burak K; Maroun J; et al. (2012). "Multidisciplinary Canadian Consensus Recommendations for the Management and Treatment of Hepatocellular Carcinoma'". Current Oncology. 18 (5): 228–40. doi:10.3747/co.v18i5.952. PMC 3185900. PMID 21980250.
- "Patient Compliance with statins" Bandolier Review 2004 Archived 2015-05-12 at Archive.today
- Krauss, Alexander (2018). "Why all randomised controlled trials produce biased results" (PDF). Annals of Medicine. 50 (4): 312–322. doi:10.1080/07853890.2018.1453233. PMID 29616838. S2CID 4971775.
- Timmermans S, Mauck A (2005). "The promises and pitfalls of evidence-based medicine". Health Aff (Millwood). 24 (1): 18–28. doi:10.1377/hlthaff.24.1.18. PMID 15647212.
- Straus, SE; McAlister, FA (3 October 2000). "Evidence-based medicine: a commentary on common criticisms" (PDF). Canadian Medical Association Journal. 163 (7): 837–41. PMC 80509. PMID 11033714.
- Cohen, AM; Stavri, PZ; Hersh, WR (February 2004). "A categorization and analysis of the criticisms of Evidence-Based Medicine" (PDF). International Journal of Medical Informatics. 73 (1): 35–43. CiteSeerX 10.1.1.586.3699. doi:10.1016/j.ijmedinf.2003.11.002. PMID 15036077. Archived from the original (PDF) on 2010-07-03.
- Upshur RE, VanDenKerkhof EG, Goel V (May 2001). "Meaning and measurement: an inclusive model of evidence in health care". J Eval Clin Pract. 7 (2): 91–96. doi:10.1046/j.1365-2753.2001.00279.x. ISSN 1356-1294. PMID 11489034.
- Rogers WA (April 2004). "Evidence based medicine and justice: a framework for looking at the impact of EBM upon vulnerable or disadvantaged groups". J Med Ethics. 30 (2): 141–45. doi:10.1136/jme.2003.007062. PMC 1733835. PMID 15082806.
- Sackett, DL; Rosenberg, WM; Gray, JA; Haynes, RB; Richardson, WS (January 1996). "Evidence based medicine: what it is and what it isn't". BMJ. 312 (7023): 71–72. doi:10.1136/bmj.312.7023.71. PMC 2349778. PMID 8555924.
- Every-Palmer S, Howick J (May 2014). "How evidence‐based medicine is failing due to biased trials and selective publication". Journal of Evaluation in Clinical Practice. 20 (6): 908–14. doi:10.1111/jep.12147. PMID 24819404.
- Friedman LS, Richter ED (January 2004). "Relationship Between Conflicts of Interest and Research Results". J Gen Intern Med. 19 (1): 51–56. doi:10.1111/j.1525-1497.2004.30617.x. PMC 1494677. PMID 14748860.
- Yitschaky O, Yitschaky M, Zadik Y (May 2011). "Case report on trial: Do you, Doctor, swear to tell the truth, the whole truth and nothing but the truth?" (PDF). J Med Case Rep. 5 (1): 179. doi:10.1186/1752-1947-5-179. PMC 3113995. PMID 21569508.
- "Knowledge Transfer in the ED: How to Get Evidence Used". Best Evidence Healthcare Blog. Archived from the original on 8 October 2013. Retrieved 8 October 2013.
- Mariotto, A. (2010). "Hypocognition and evidence-based medicine". Internal Medicine Journal. 40 (1): 80–82. doi:10.1111/j.1445-5994.2009.02086.x. PMID 20561370.
- Yamada, Seiji; Slingsby, Brian Taylor; Inada, Megan K.; Derauf, David (2008-06-01). "Evidence-based public health: a critical perspective". Journal of Public Health. 16 (3): 169–172. doi:10.1007/s10389-007-0156-7. ISSN 0943-1853. S2CID 652725.
- Kelly, M; Heath, I; Howick, J; Greenhalgh, T (2015). "The importance of values in evidence-based medicine". BMC Medical Ethics. 16 (69): 69. doi:10.1186/s12910-015-0063-3. PMC 4603687. PMID 26459219.
- Fulford, KWM; Peile, H; Carroll, H (March 2012). Essential Values-Based Practice. ISBN 978-0-521-53025-5.
- Epstein, David (2017-02-22). "When Evidence Says No, But Doctors Say Yes". ProPublica. Retrieved 2017-02-24.
- Herrera-Perez, Diana; Haslam, Alyson; Crain, Tyler; Gill, Jennifer; Livingston, Catherine; Kaestner, Victoria; Hayes, Michael; Morgan, Dan; Cifu, Adam S (2019-06-11). "A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals". eLife. 8: e45183. doi:10.7554/eLife.45183. PMC 6559784. PMID 31182188.
- Dawes, M; Summerskill, W; Glasziou, P; Cartabellotta, A; Martin, J; Hopayian, K; Porzsolt, F; Burls, A; Osborne, J; Second International Conference of Evidence-Based Health Care Teachers and, Developers. (5 January 2005). "Sicily statement on evidence-based practice". BMC Medical Education. 5 (1): 1. doi:10.1186/1472-6920-5-1. PMC 544887. PMID 15634359.
- Fritsche, L.; Greenhalgh, T.; Falck-Ytter, Y.; Neumayer, H.H.; Kunz, R. (2002). "Do short courses in evidence based medicine improve knowledge and skills? Validation of Berlin questionnaire and before and after study of courses in evidence based medicine". BMJ (Clinical Research Ed.). 325 (7376): 1338–41. doi:10.1136/bmj.325.7376.1338. PMC 137813. PMID 12468485.
- Ramos, K.D.; Schafer, S.; Tracz, S.M. (2003). "Validation of the Fresno test of competence in evidence based medicine". BMJ. 326 (7384): 319–21. doi:10.1136/bmj.326.7384.319. PMC 143529. PMID 12574047.
- Shaneyfelt, T.; Baum, K.D.; Bell, D.; Feldstein, D.; Houston, TK; Kaatz, S; Whelan, C.; Green, M (2006). "Instruments for evaluating education in evidence-based practice: a systematic review". JAMA. 296 (9): 1116–27. doi:10.1001/jama.296.9.1116. PMID 16954491.
- Straus SE, Green ML, Bell DS, Badgett R, Davis D, Gerrity M, et al. (2004). "Evaluating the teaching of evidence based medicine: conceptual framework". BMJ. 329 (7473): 1029–32. doi:10.1136/bmj.329.7473.1029. PMC 524561. PMID 15514352.
- Kunz, R.; Wegscheider, K.; Fritsche, L.; Schünemann, H.J.; Moyer, V.; Miller, D.; Boluyt, L.; Falck-Ytter, Y.; Griffiths, P.; Bucher, H.C.; Timmer, A.; Meyerrose, J; Witt, K.; Dawes; Greenhalgh, T.; Guyatt, G.H. (2010). "Determinants of knowledge gain in evidence-based medicine short courses: an international assessment". Open Med. 4 (1): e3–e10. doi:10.2174/1874104501004010003. PMC 3116678. PMID 21686291.
- West CP, Jaeger TM, McDonald FS (2011). "Extended evaluation of a longitudinal medical school evidence-based medicine curriculum". J Gen Intern Med. 26 (6): 611–15. doi:10.1007/s11606-011-1642-8. PMC 3101983. PMID 21286836.
- Rohwer, Anke; Motaze, Nkengafac Villyen; Rehfuess, Eva; Young, Taryn (2017). "E-learning of evidence-based health care (EBHC) to increase EBHC competencies in healthcare professionals: a systematic review". Campbell Systematic Reviews. 4: 1–147. doi:10.4073/csr.2017.4.
- Azzam, A.; Bresler, D.; Leon, A.; Maggio, L.; Whitaker, E.; Heilman, J.; Orlowitz, J.; Swisher, V.; Rasberry, L.; Otoide, K.; Trotter, F.; Ross, W.; McCue, J.D. (February 2017). "Why Medical Schools Should Embrace Wikipedia: Final-Year Medical Student Contributions to Wikipedia Articles for Academic Credit at One School". Academic Medicine. 92 (2): 194–200. doi:10.1097/ACM.0000000000001381. PMC 5265689. PMID 27627633.
- Doi, S.A.R. (2012). Understanding evidence in health care: Using clinical epidemiology. South Yarra, VIC, Australia: Palgrave Macmillan. ISBN 978-1-4202-5669-7.
- Grobbee, D.E.; Hoes, Arno W. (2009). Clinical Epidemiology: Principles, Methods, and Applications for Clinical Research. Jones & Bartlett Learning. ISBN 978-0-7637-5315-3.
- Howick, Jeremy H. (2011). The Philosophy of Evidence-based Medicine. Wiley. ISBN 978-1-4051-9667-3.
- Katz, David L. (2001). Clinical Epidemiology & Evidence-Based Medicine: Fundamental Principles of Clinical Reasoning & Research. SAGE. ISBN 978-0-7619-1939-1.
- Stegenga, Jacob (2018). Care and Cure: An Introduction To Philosophy of Medicine. University of Chicago Press. ISBN 978-0-226-59517-7.
|Look up evidence-based medicine in Wiktionary, the free dictionary.|