Exatecan

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Exatecan
Exatecan.svg
Names
IUPAC name
(1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione
Identifiers
3D model (JSmol)
ChemSpider
UNII
Properties
C24H22FN3O4
Molar mass 435.447583
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Exatecan is a drug which is an analogue of camptothecin with antineoplastic activity.[1]

Synthesis[edit]

Exatecan synthesis[2]

References[edit]

  1. ^ Abou-Alfa, GK; Letourneau, R; Harker, G; Modiano, M; Hurwitz, H; Tchekmedyian, NS; Feit, K; Ackerman, J; De Jager, RL; Eckhardt, SG; O'Reilly, EM (20 September 2006). "Randomized Phase III Study of Exatecan and Gemcitabine Compared with Gemcitabine Alone in Untreated Advanced Pancreatic Cancer" (PDF). Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 24 (27): 4441–7. doi:10.1200/JCO.2006.07.0201. PMID 16983112. Retrieved 15 July 2016. 
  2. ^ H. Terasawa, A. Ejima, S. Ohsuki, K. Uoto, U.S. Patent 5,834,476 (1998).