Excitatory amino-acid transporter 4

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Solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Symbols SLC1A6 ; EAAT4
External IDs OMIM600637 MGI1096331 HomoloGene21055 IUPHAR: 871 ChEMBL: 3173 GeneCards: SLC1A6 Gene
Species Human Mouse
Entrez 6511 20513
Ensembl ENSG00000105143 ENSMUSG00000005357
UniProt P48664 O35544
RefSeq (mRNA) NM_001272087 NM_009200
RefSeq (protein) NP_001259016 NP_033226
Location (UCSC) Chr 19:
14.95 – 15.02 Mb
Chr 10:
78.78 – 78.81 Mb
PubMed search [1] [2]

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.[1][2]

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.[2]


  1. ^ "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)". 
  2. ^ a b Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature 375 (6532): 599–603. doi:10.1038/375599a0. PMID 7791878. 

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