Excitatory amino-acid transporter 4

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SLC1A6
Identifiers
Aliases SLC1A6, EAAT4, solute carrier family 1 member 6
External IDs OMIM: 600637 MGI: 1096331 HomoloGene: 21055 GeneCards: SLC1A6
Targeted by Drug
DL-TBOA[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001272087
NM_001272088
NM_005071

NM_009200

RefSeq (protein)

NP_001259016
NP_001259017
NP_005062

NP_033226.1
NP_033226

Location (UCSC) Chr 19: 14.95 – 15.02 Mb Chr 10: 78.78 – 78.81 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.[4][5]

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.[5]

References[edit]

  1. ^ "Drugs that physically interact with Solute carrier family 1 member 6 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)". 
  5. ^ a b Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature. 375 (6532): 599–603. doi:10.1038/375599a0. PMID 7791878. 

Further reading[edit]