Excitatory amino-acid transporter 5

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Solute carrier family 1 (glutamate transporter), member 7
Symbols SLC1A7 ; AAAT; EAAT5
External IDs OMIM604471 MGI2444087 HomoloGene21327 IUPHAR: 872 ChEMBL: 4390 GeneCards: SLC1A7 Gene
Species Human Mouse
Entrez 6512 242607
Ensembl ENSG00000162383 ENSMUSG00000008932
UniProt O00341 Q8JZR4
RefSeq (mRNA) NM_001287595 NM_146255
RefSeq (protein) NP_001274524 NP_666367
Location (UCSC) Chr 1:
53.09 – 53.14 Mb
Chr 4:
107.97 – 108.01 Mb
PubMed search [1] [2]

Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.[1][2]

EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.[2]


Further reading[edit]

  • Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Wistow G, Bernstein SL, Ray S; et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis. 8: 185–95. PMID 12107412. 
  • Boehmer C, Rajamanickam J, Schniepp R; et al. (2005). "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3.". Biochem. Biophys. Res. Commun. 329 (2): 738–42. doi:10.1016/j.bbrc.2005.02.035. PMID 15737648. 
  • Gratacòs M, Costas J, de Cid R; et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.