|Exelixis Pharmaceuticals, Inc.|
|Headquarters||Alameda, California, U.S.|
|Stelios Papadopoulos, Ph.D.|
Michael M. Morrissey, Ph.D.
(President & CEO)
|Revenue||US$ 853.8 million (2018)|
|US$ 165.91 million (2017)|
|US$ 154.23 million (2017)|
|Total assets||US$ 655.29 million (2017)|
|Total equity||US$ 284.96 million (2017)|
Number of employees
|ca. 350 (2017)|
|Footnotes / references|
Exelixis, Inc. is a genomics-based drug discovery company located in Alameda, California, and the producer of Cometriq, a treatment approved by the U.S. Food and Drug Administration (FDA) for medullary thyroid cancer with clinical activity in several other types of metastatic cancer.
Exelixis was founded in 1994; the scientific founders were Spyridon Artavanis–Tsakonas, at Yale at that time, and Corey Goodman and Gerry Rubin who were then at the University of California, Berkeley. George Scangos joined the company as CEO in 1996. The business plan was to use model organisms (fruit flies, nematodes, and zebrafish) and functional genomics to identify pathways and biological targets that could be exploited in the fields of agriculture and medicine. It eventually set up a subsidiary, Exelixis Plant Sciences, for the agricultural work.
By 2000 it had left the radical exploratory phase behind and became focused on drug discovery and had a chemical library of 4 million compounds. The company went public that year, after withdrawing its offering the week before; it raised $118 million in a down market.
In 2002 the company signed a broad alliance with GSK to discover new drugs in the fields of cancer, inflammatory diseases, and vascular conditions; GSK paid it $30 million in cash, bought $14 million in stock at twice the market rate, and committed to providing Exelixis with $90 million in research funding; it also offered loan financing of up to $85 million.
By 2002 the company had limited its internal efforts to cancer, and had settled its strategy on discovering and developing drugs that could inhibit targeted small sets of tyrosine kinases that are needed for cancer formation, growth, and metastasis. The sets of TKs had been identified by means of its prior functional genomics work. This approach was controversial at the time; most companies try to selectively target just one protein in their discovery efforts.
In 2006 Exelixis partnered with Daiichi Sankyo on compounds that targeted mineralocorticoid receptors; esaxerenone was part of this collaboration. In 2007, the company partnered its MEK inhibitor program with Genentech; cobimetinib (at that time XL-518) was part of this collaboration. Exelixis had filed an IND on XL-518 prior to the partnership, committed to funding and running the Phase I trial, and retained rights to co-market it in the US.
In 2008 the company partnered its lead cancer drug candidate, XL-184 (which would become called cabozantinib) and another cancer candidate, XL-281, with Bristol Myers Squibb; BMS returned the rights to XL-184 to Exelixis in 2010 and returned the rights to other drug candidate in 2011.
In 2010 Scangos departed as CEO to take over at Biogen and the company appointed Michael M. Morrissey as President and CEO; Morrissey had joined the company in 2000 as Vice President of Discovery Research. At that time the company had eight drugs in clinical trials.
Exelixis invested heavily in exploring cabozantinib in other cancers, betting the future of the company on the drug. In 2014 the drug failed a Phase III trial in prostate cancer, and the company laid off 70% of its employees.
In 2015 Genentech and Exelixis won FDA approval for cobimetinib for certain forms of melanoma.
- "US SEC: Form 10-K Exelixis, Inc". U.S. Securities and Exchange Commission. Retrieved March 4, 2018.
- McCarthy, Alice A. (April 2005). "Exelixis: Integrated Drug-Discovery and Development Platform for Human Therapeutics" (PDF). Chemistry & Biology. 12 (4): 407–408. doi:10.1016/j.chembiol.2005.04.004. PMID 15850973.
- McBride, Ryan (30 June 2010). "Reports: Biogen Picks Exelixis Chief George Scangos as New CEO". Xconomy.
- "Exelixis IPO defies ill-tempered market". MarketWatch. Apr 11, 2000.
- Pollack, Andrew (29 October 2002). "Glaxo Forms An Alliance In Biotech". The New York Times.
- "Press release: Daiichi Sankyo Initiates Phase 3 study of CS-3150, a Novel Mineralocorticoid Receptor Antagonist for Treatment of Essential Hypertension". Daiichi Sankyo. September 27, 2016.
- "Exelixis, Genentech Enter Onco-Development Pact". Contract Pharma. January 3, 2007.
- Leuty, Ron (June 21, 2010). "Exelixis falls as BMS returns cancer drug". San Francisco Business Times.
- Leuty, Ron (July 14, 2011). "Bristol-Myers Squibb returns rights to Exelixis cancer drug". San Francisco Business Times.
- "Press release: Exelixis Inc Announces Appointment of New CEO Michael Morrissey". Exelixis via Biospace. June 30, 2010.
- Herper, Matthew (December 4, 2012). "Biotech's Comeback Kid". Forbes.
- "Press release: FDA approves Cometriq to treat rare type of thyroid cancer". FDA. 29 November 2012. Archived from the original on July 7, 2014.
- "Cometriq Summary". EMA. Retrieved 8 August 2017.
- Lash, Alex (1 June 2015). "At Exelixis, Morrissey Dreams Of Getting the Band Back Together". Xconomy.
- Leuty, Ron (November 10, 2015). "Big new-drug win for skin cancer patients, two Bay Area biotechs". San Francisco Business Times.
- Garde, Damian (March 1, 2016). "Ipsen bets up to $855M on Exelixis' once-failed cancer drug". FierceBiotech.
- FDA Approval Announcement, April 2016
- "Cabometyx summary". EMA. Retrieved 8 August 2017.
- FDA grants regular approval to Cabometyx for first-line treatment of advanced renal cell carcinoma
- Exelixis' Cabometyx Gets EU Nod for First-Line Kidney Cancer
|Wikimedia Commons has media related to Exelixis.|
- Official website
- Business data for Exelixis, Inc.: