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Exo-1,4-beta-D-glucosaminidase (EC, CsxA, GlcNase, exochitosanase, GlmA, exo-beta-D-glucosaminidase, chitosan exo-1,4-beta-D-glucosaminidase) is an enzyme with systematic name chitosan exo-(1->4)-beta-D-glucosaminidase.[1][2][3]![4][5] This enzyme catalyses the following chemical reaction

Hydrolysis of chitosan or chitosan oligosaccharides to remove successive D-glucosamine residues from the non-reducing termini

Chitosan is a partially or totally N-deacetylated chitin derivative that is found in the cell walls of some phytopathogenic fungi .


  1. ^ Nanjo, F.; Katsumi, R.; Sakai, K. (1990). "Purification and characterization of an exo-β-D-glucosaminidase, a novel type of enzyme, from Nocardia orientalis". J. Biol. Chem. 265: 10088–10094. PMID 2351651. 
  2. ^ Nogawa, M.; Takahashi, H.; Kashiwagi, A.; Ohshima, K.; Okada, H.; Morikawa, Y. (1998). "Purification and characterization of exo-β-D-glucosaminidase from a cellulolytic fungus, Trichoderma reesei PC-3-7". Appl. Environ. Microbiol. 64: 890–895. PMC 106342Freely accessible. PMID 16349528. 
  3. ^ Fukamizo, T.; Fleury, A.; Côté, N.; Mitsutomi, M.; Brzezinski, R. (2006). "Exo-β-D-glucosaminidase from Amycolatopsis orientalis: catalytic residues, sugar recognition specificity, kinetics, and synergism". Glycobiology. 16: 1064–1072. doi:10.1093/glycob/cwl026. PMID 16877749. 
  4. ^ Côté, N.; Fleury, A.; Dumont-Blanchette, E.; Fukamizo, T.; Mitsutomi, M.; Brzezinski, R. (2006). "Two exo-β-D-glucosaminidases/exochitosanases from actinomycetes define a new subfamily within family 2 of glycoside hydrolases". Biochem. J. 394: 675–686. doi:10.1042/bj20051436. PMC 1383717Freely accessible. PMID 16316314. 
  5. ^ Ike, M.; Isami, K.; Tanabe, Y.; Nogawa, M.; Ogasawara, W.; Okada, H.; Morikawa, Y. (2006). "Cloning and heterologous expression of the exo-β-D-glucosaminidase-encoding gene (gls93) from a filamentous fungus, Trichoderma reesei PC-3-7". Appl. Microbiol. Biotechnol. 72: 687–695. doi:10.1007/s00253-006-0320-y. PMID 16636831. 

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