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For the software company, see Exosite (company).

An exosite is a secondary binding site, remote from the active site, on an enzyme or other protein.[1]

This is similar to allosteric sites, but differs in the fact that, in order for an enzyme to be active, its exosite typically must be occupied.[2] Exosites have recently become a topic of increased interest in biomedical research as potential drug targets.[3][4]


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