Exosome component 1

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EXOSC1
Protein EXOSC1 PDB 2nn6.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEXOSC1, CGI-108, CSL4, Csl4p, SKI4, Ski4p, hCsl4p, p13, Exosome component 1
External IDsOMIM: 606493 MGI: 1913833 HomoloGene: 9359 GeneCards: EXOSC1
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for EXOSC1
Genomic location for EXOSC1
Band10q24.1Start97,435,909 bp[1]
End97,446,017 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164561
NM_025644
NM_001320231
NM_001320232
NM_001320233

RefSeq (protein)

NP_001158033
NP_001307160
NP_001307161
NP_001307162
NP_079920

Location (UCSC)Chr 10: 97.44 – 97.45 MbChr 19: 41.92 – 41.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene.[5][6][7]

This gene encodes a core component of the exosome complex. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.[7]

Interactions[edit]

Exosome component 1 has been shown to interact with:

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171311 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034321 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J Mol Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
  6. ^ Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
  7. ^ a b "Entrez Gene: EXOSC1 exosome component 1".
  8. ^ a b c Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. PMID 12419256.

Further reading[edit]