Expression Atlas

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Expression Atlas
Content
DescriptionGene expression across species and conditions
Data types
captured
Microarray Data and other Gene Expression
OrganismsHuman, Mouse, Rat, Fruit-fly, Chicken, Roundworm, Wild boar, Zebrafish, Cow and others.
Contact
Research centerEMBL-EBI
Primary citationPMID 31665515
Release dateMarch 2020
Access
Websitewww.ebi.ac.uk/gxa/home
Tools
WebAdvanced search, bulk retrieval/download
Miscellaneous
Data release
frequency
3 to 4 times a year
Curation policyManual curation of every study.

The Expression Atlas is a database maintained by the European Bioinformatics Institute that provides information on gene expression patterns from RNA-Seq and Microarray studies, and protein expression from Proteomics studies.[1] The Expression Atlas allows searches by gene, splice variant, protein attribute, disease, treatment or organism part (cell types/tissues). Individual genes or gene sets can be searched for. All datasets in Expression Atlas have its metadata manually curated and its data analysed through standardised analysis pipelines. There are two components to the Expression Atlas, the Baseline Atlas and the Differential Atlas:

Baseline Atlas[edit]

The Baseline Atlas provides information about which gene products are present (and at what abundance) under "normal" conditions. This component of the Expression Atlas consists of RNA-seq experiments from ArrayExpress repositories. It aims to answer questions such as:

  • Which genes are specifically expressed in kidney?
  • What is the expression pattern for gene SAA4 in normal tissues?

Differential Atlas[edit]

The Differential Atlas allows users to identify genes that are up- or down-regulated in different experimental conditions.

See also[edit]

References[edit]

  1. ^ Papatheodorou I, Moreno P, Manning J, Fuentes AM, George N, Fexova S, et al. (Jan 2020). "Expression Atlas update: from tissues to single cells". Nucleic Acids Research. 48 (D1): D77–D83. doi:10.1093/nar/gkz947. PMC 7145605. PMID 31665515.

Further reading[edit]

External links[edit]