Extended-spectrum penicillin

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The extended-spectrum penicillins are a group of antibiotics that have the widest antibacterial spectrum of all penicillins.[1] Some sources identify them with antipseudomonal penicillins,[2] others consider these types to be distinct.[3] This group includes the carboxypenicillins and the ureidopenicillins. Aminopenicillins, in contrast, do not have activity against Pseudomonas species, as their positively charged amino group does not hinder degradation by bacterially produced beta-lactamases.[4]

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  1. ^ Comprehensive Pharmacy Review, Leon Shargel, 6th edition, p917
  2. ^ Kester, Mark; Karpa, Kelly Dowhower; Vrana, Kent E. (2011). Elsevier's Integrated Review Pharmacology E-Book. Elsevier Health Sciences. ISBN 9781455727032.
  3. ^ Clark, Michelle A.; Harvey, Richard A.; Finkel, Richard; Rey, Jose A.; Whalen, Karen, eds. (2011). Pharmacology. Lippincott Williams & Wilkins. p. 383. ISBN 9781451113143.
  4. ^ Golan, David E. Principles of Pharmacology (2 ed.). Lippincott Williams & Wilkins. p. 610. ISBN 1608312704.