Extrachromosomal rDNA circle

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Extrachromosomal rDNA circles (ERC) are self replicating circles of ribosomal DNA found in some strains of yeast and thought to contribute to their aging.[1] [2] [3]

The ERC accumulate in the mother cell during the budding process.[3]

They are a type of Extrachromosomal Circular DNA (eccDNA),[4] a type of Extrachromosomal DNA.

See also[edit]


  1. ^ Sinclair DA, Guarente L (1997). "Extrachromosomal rDNA circles--a cause of aging in yeast.". 91 (7): 1033–42. doi:10.1016/S0092-8674(00)80493-6. PMID 9428525. 
  2. ^ "Molecular Mechanisms of Yeast Lifespan Extension by Calorie Restriction". Dec 2007. 
  3. ^ a b Nyström (2007). "A Bacterial Kind of Aging". 
  4. ^ Cohen at al. (2003). "Extrachromosomal Circular DNA of Tandemly Repeated Genomic Sequences in Drosophila".