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Ezem (Hebrew: עצם‎, vars. ‛Atsem or Otzem, meaning strength) is an unidentified site in the Negeb of Judah toward the Edomite border. It is mentioned in the Biblical Book of Joshua(15:29; 19:1-3). In the King James Version it is spelled "Azem" in Joshua and "Ezem" in Chronicles (4:29).

In Joshua 19:1-3 and 1 Chronicles 4:29 it is one of the towns "in the midst of the inheritance of Judah" assigned to Simeon.[1]