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F16, F 16, F-16 or FI6 may refer to:
- General Dynamics F-16 Fighting Falcon, a 1974 American multirole fighter jet aircraft
- FI6 (antibody), an antibody that targets influenza A viruses
- F 16 Uppsala, a Swedish air force base
- Formula 16, a 5 metre catamaran
- Volvo F16, a truck
- The ICD-10 code for "mental and behavioural disorders due to use of hallucinogens"
- Eric Fehr, a Canadian ice hockey player and author who wears #16 for the Toronto Maple Leafs of the National Hockey League
- Half-precision floating-point format, a 16-bit computer number format
- Shibuya Station, coded as on the Fukutoshin Line
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