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F16, F 16, F-16 or FI6 may refer to:
- General Dynamics F-16 Fighting Falcon, a 1974 American multirole jet fighter aircraft
- FI6 (antibody), an antibody that targets influenza A viruses
- F 16 Uppsala, a Swedish air force base
- Formula 16, a 5 metre catamaran
- Volvo F16, a truck
- the ICD-10 code for mental and behavioural disorders due to use of hallucinogens
- Eric Fehr, a Canadian ice hockey player and author who wears #16 for the Washington Capitals of the National Hockey League
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