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F18, F-18 or F.XVIII may refer to:
- F/A-18 Hornet, a 1978 American all-weather carrier-capable strike fighter jet
- F-18 (Michigan county highway)
- Fokker F.XVIII, a 1932 Dutch airliner
- HMS Zulu (F18), a 1937 British Royal Navy Tribal-class destroyer
- Formula 18 Catamaran
- Fluorine-18, an unstable isotope of fluorine
- F-18, Docking Slip for the "Busted Flush"
- the ICD-10 code for mental and behavioural disorders due to use of volatile solvents
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