F2RL2

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F2RL2
Identifiers
Aliases F2RL2, PAR-3, PAR3, coagulation factor II thrombin receptor like 2
External IDs MGI: 1298208 HomoloGene: 36151 GeneCards: 2151
RNA expression pattern
PBB GE F2RL2 206795 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004101
NM_001256566

NM_010170

RefSeq (protein)

NP_001243495.1
NP_004092.1

NP_034300.3

Location (UCSC) Chr 5: 76.62 – 76.62 Mb Chr 13: 95.7 – 95.7 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.

Function[edit]

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to G proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.[1]

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.