F2RL3

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F2RL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesF2RL3, PAR4, F2R like thrombin/trypsin receptor 3, F2R like thrombin or trypsin receptor 3
External IDsMGI: 1298207 HomoloGene: 36148 GeneCards: F2RL3
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for F2RL3
Genomic location for F2RL3
Band19p13.11Start16,888,860 bp[1]
End16,892,606 bp[1]
RNA expression pattern
PBB GE F2RL3 207221 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003950

NM_007975

RefSeq (protein)

NP_003941

NP_032001

Location (UCSC)Chr 19: 16.89 – 16.89 MbChr 8: 72.76 – 72.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.[5]

Function[edit]

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.[5]

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.