F2RL3

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F2RL3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases F2RL3, PAR4, F2R like thrombin/trypsin receptor 3
External IDs MGI: 1298207 HomoloGene: 36148 GeneCards: 9002
RNA expression pattern
PBB GE F2RL3 207221 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003950

NM_007975

RefSeq (protein)

NP_003941.2

NP_032001.2

Location (UCSC) Chr 19: 16.89 – 16.89 Mb Chr 8: 72.76 – 72.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.[1]

Function[edit]

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.[1]

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.