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Fatty acid binding protein 2, intestinal
Protein FABP2 PDB 1kzw.png
PDB rendering based on 1kzw.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM134640 MGI95478 HomoloGene107 ChEMBL: 4879 GeneCards: FABP2 Gene
RNA expression pattern
PBB GE FABP2 207475 at tn.png
More reference expression data
Species Human Mouse
Entrez 2169 14079
Ensembl ENSG00000145384 ENSMUSG00000023057
UniProt P12104 P55050
RefSeq (mRNA) NM_000134 NM_007980
RefSeq (protein) NP_000125 NP_032006
Location (UCSC) Chr 4:
119.32 – 119.32 Mb
Chr 3:
122.9 – 122.9 Mb
PubMed search [1] [2]

Fatty acid-binding protein 2 (FABP2) also known as Intestinal-type fatty acid-binding protein (I-FABP) is a protein that in humans is encoded by the FABP2 gene.[1]


The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells.[1]

Clinical significance[edit]

This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.[1]


Further reading[edit]