FABP2

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FABP2
Protein FABP2 PDB 1kzw.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FABP2, FABPI, I-FABP, fatty acid binding protein 2
External IDs MGI: 95478 HomoloGene: 107 GeneCards: FABP2
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for FABP2
Genomic location for FABP2
Band 4q26 Start 119,317,250 bp[1]
End 119,322,390 bp[1]
RNA expression pattern
PBB GE FABP2 207475 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000134

NM_007980

RefSeq (protein)

NP_000125

NP_032006

Location (UCSC) Chr 4: 119.32 – 119.32 Mb Chr 4: 122.9 – 122.9 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fatty acid-binding protein 2 (FABP2) also known as Intestinal-type fatty acid-binding protein (I-FABP) is a protein that in humans is encoded by the FABP2 gene.[5]

Function[edit]

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells.[5]

Clinical significance[edit]

This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.[5]

References[edit]

Further reading[edit]