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Fatty acid binding protein 5 (psoriasis-associated)
Protein FABP5 PDB 1b56.png
PDB rendering based on 1b56.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM605168 HomoloGene108238 ChEMBL: 3674 GeneCards: FABP5 Gene
Species Human Mouse
Entrez 2171 16592
Ensembl ENSG00000164687 ENSMUSG00000027533
UniProt Q01469 Q05816
RefSeq (mRNA) NM_001444 NM_001272097
RefSeq (protein) NP_001435 NP_001259026
Location (UCSC) Chr 8:
81.28 – 81.28 Mb
Chr 3:
10.01 – 10.02 Mb
PubMed search [1] [2]

Fatty acid-binding protein, epidermal is a protein that in humans is encoded by the FABP5 gene.[1][2]

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.[2]


FABP5 has been shown to interact with S100A7.[3][4]


  1. ^ Madsen P, Rasmussen HH, Leffers H, Honore B, Celis JE (Sep 1992). "Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins". J Invest Dermatol 99 (3): 299–305. doi:10.1111/1523-1747.ep12616641. PMID 1512466. 
  2. ^ a b "Entrez Gene: FABP5 fatty acid binding protein 5 (psoriasis-associated)". 
  3. ^ Ruse, Monica; Broome Ann-Marie; Eckert Richard L (Jul 2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". J. Invest. Dermatol. (United States) 121 (1): 132–41. doi:10.1046/j.1523-1747.2003.12309.x. ISSN 0022-202X. PMID 12839573. 
  4. ^ Hagens, G; Roulin K; Hotz R; Saurat J H; Hellman U; Siegenthaler G (Feb 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Mol. Cell. Biochem. (NETHERLANDS) 192 (1–2): 123–8. doi:10.1023/A:1006894909694. ISSN 0300-8177. PMID 10331666. 

Further reading[edit]