FABP7

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FABP7
Protein FABP7 PDB 1fdq.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FABP7, B-FABP, BLBP, FABPB, MRG, LTR2-fatty acid binding protein 7
External IDs MGI: 101916 HomoloGene: 37880 GeneCards: 2173
RNA expression pattern
PBB GE FABP7 205029 s at tn.png

PBB GE FABP7 205030 at tn.png

PBB GE FABP7 216192 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001446
NM_001319039
NM_001319041
NM_001319042

NM_021272

RefSeq (protein)

NP_001437.1

NP_067247.1

Location (UCSC) Chr 6: 122.78 – 122.78 Mb Chr 10: 57.78 – 57.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.[1]

Function[edit]

The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.[1]

FABP7 is expressed, during development, in radial glia by the activation of Notch receptors.[2] Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation.[3]

According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.[4]

Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.

Role in pathology[edit]

FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.[5]

As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia,[6] with one, that tested for only one SNP, showing negative[7] and another, with seven SNPs,[8] a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.

References[edit]

  1. ^ a b "Entrez Gene: FABP7 fatty acid binding protein 7, brain". 
  2. ^ Anthony TE, Mason HA, Gridley T, Fishell G, Heintz N (May 2005). "Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells". Genes & Development 19 (9): 1028–33. doi:10.1101/gad.1302105. PMC 1091737. PMID 15879553. 
  3. ^ Keilani S, Sugaya K (July 2008). "Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1". BMC Developmental Biology 8 (1): 69. doi:10.1186/1471-213X-8-69. PMC 2447831. PMID 18593473. 
  4. ^ Xu LZ, Sánchez R, Sali A, Heintz N (Oct 1996). "Ligand specificity of brain lipid-binding protein". The Journal of Biological Chemistry 271 (40): 24711–9. doi:10.1074/jbc.271.40.24711. PMID 8798739. 
  5. ^ Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lönnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoëga T, Helgason T (Jul 2003). "Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia". American Journal of Human Genetics 73 (1): 34–48. doi:10.1086/376549. PMC 1180588. PMID 12802786. 
  6. ^ Gene Overview of All Published Schizophrenia-Association Studies for FABP7 - SZGene database at Schizophrenia Research Forum website.
  7. ^ Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't Slot R, Bardoel AF, Ophoff RA, Wijmenga C, Kahn RS, Sinke RJ (Nov 2008). "An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia". Molecular Psychiatry 13 (11): 1060–8. doi:10.1038/sj.mp.4002080. PMID 17893707. 
  8. ^ Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, Matsumata M, Ishitsuka Y, Nakaya A, Maekawa M, Ohnishi T, Arai R, Sakurai K, Yamada K, Kondo H, Hashimoto K, Osumi N, Yoshikawa T (Nov 2007). "Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype". PLoS Biology 5 (11): e297. doi:10.1371/journal.pbio.0050297. PMC 2071943. PMID 18001149. 

Further reading[edit]

External links[edit]