FAF1

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FAF1
Protein FAF1 PDB 1h8c.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FAF1, HFAF1s, UBXD12, UBXN3A, hCGI-03, Fas associated factor 1
External IDs MGI: 109419 HomoloGene: 5120 GeneCards: FAF1
Genetically Related Diseases
type 2 diabetes mellitus, Alcohol dependence[1]
RNA expression pattern
PBB GE FAF1 218080 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_131917
NM_007051

NM_007983

RefSeq (protein)

NP_008982

NP_032009.2
NP_032009

Location (UCSC) Chr 1: 50.44 – 50.96 Mb Chr 4: 109.68 – 109.96 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene.[4][5]

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.[5]

References[edit]

  1. ^ "Diseases that are genetically associated with FAF1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Ryu SW, Chae SK, Lee KJ, Kim E (Oct 1999). "Identification and characterization of human Fas associated factor 1, hFAF1". Biochem Biophys Res Commun. 262 (2): 388–94. doi:10.1006/bbrc.1999.1217. PMID 10462485. 
  5. ^ a b "Entrez Gene: FAF1 Fas (TNFRSF6) associated factor 1". 

Further reading[edit]