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Fanconi anemia, complementation group F
Protein FANCF PDB 2iqc.png
PDB rendering based on 2iqc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FANCF ; FAF
External IDs OMIM613897 HomoloGene75185 GeneCards: FANCF Gene
RNA expression pattern
PBB GE FANCF 218689 at tn.png
More reference expression data
Species Human Mouse
Entrez 2188 100040608
Ensembl ENSG00000183161 ENSMUSG00000092118
UniProt Q9NPI8 E9Q5Z5
RefSeq (mRNA) NM_022725 NM_001115087
RefSeq (protein) NP_073562 NP_001108559
Location (UCSC) Chr 11:
22.62 – 22.63 Mb
Chr 7:
51.86 – 51.86 Mb
PubMed search [1] [2]

Fanconi anemia group F protein is a protein that in humans is encoded by the FANCF gene.[1][2]


FANCF has been shown to interact with Fanconi anemia, complementation group C,[3][4] FANCG,[3][4][5][6] FANCA[3][4][7] and FANCE.[3][8]


  1. ^ Joenje H, Oostra AB, Wijker M, di Summa FM, van Berkel CG, Rooimans MA, Ebell W, van Weel M, Pronk JC, Buchwald M, Arwert F (November 1997). "Evidence for at least eight Fanconi anemia genes". Am J Hum Genet 61 (4): 940–4. doi:10.1086/514881. PMC 1715980. PMID 9382107. 
  2. ^ "Entrez Gene: FANCF Fanconi anemia, complementation group F". 
  3. ^ a b c d Léveillé, France; Blom Eric, Medhurst Annette L, Bier Patrick, Laghmani El Houari, Johnson Mark, Rooimans Martin A, Sobeck Alexandra, Waisfisz Quinten, Arwert Fré, Patel K J, Hoatlin Maureen E, Joenje Hans, de Winter Johan P (September 2004). "The Fanconi anemia gene product FANCF is a flexible adaptor protein". J. Biol. Chem. (United States) 279 (38): 39421–30. doi:10.1074/jbc.M407034200. ISSN 0021-9258. PMID 15262960. 
  4. ^ a b c de Winter, J P; van der Weel L; de Groot J; Stone S; Waisfisz Q; Arwert F; Scheper R J; Kruyt F A; Hoatlin M E; Joenje H (November 2000). "The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG". Hum. Mol. Genet. (ENGLAND) 9 (18): 2665–74. doi:10.1093/hmg/9.18.2665. ISSN 0964-6906. PMID 11063725. 
  5. ^ Gordon, Susan M; Buchwald Manuel (July 2003). "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems". Blood (United States) 102 (1): 136–41. doi:10.1182/blood-2002-11-3517. ISSN 0006-4971. PMID 12649160. 
  6. ^ Medhurst, A L; Huber P A; Waisfisz Q; de Winter J P; Mathew C G (February 2001). "Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway". Hum. Mol. Genet. (England) 10 (4): 423–9. doi:10.1093/hmg/10.4.423. ISSN 0964-6906. PMID 11157805. 
  7. ^ Meetei, Amom Ruhikanta; de Winter Johan P, Medhurst Annette L, Wallisch Michael, Waisfisz Quinten, van de Vrugt Henri J, Oostra Anneke B, Yan Zhijiang, Ling Chen, Bishop Colin E, Hoatlin Maureen E, Joenje Hans, Wang Weidong (October 2003). "A novel ubiquitin ligase is deficient in Fanconi anemia". Nat. Genet. (United States) 35 (2): 165–70. doi:10.1038/ng1241. ISSN 1061-4036. PMID 12973351. 
  8. ^ Pace, Paul; Johnson Mark; Tan Wu Meng; Mosedale Georgina; Sng Chelvin; Hoatlin Maureen; de Winter Johan; Joenje Hans; Gergely Fanni; Patel K J (July 2002). "FANCE: the link between Fanconi anaemia complex assembly and activity". EMBO J. (England) 21 (13): 3414–23. doi:10.1093/emboj/cdf355. ISSN 0261-4189. PMC 125396. PMID 12093742. 

Further reading[edit]