FARP1

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FARP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FARP1, CDEP, FARP1-IT1, PLEKHC2, PPP1R75, FERM, ARH/RhoGEF and pleckstrin domain protein 1
External IDs MGI: 2446173 HomoloGene: 38098 GeneCards: FARP1
Genetically Related Diseases
obesity, fatty liver disease[1]
RNA expression pattern
PBB GE FARP1 201910 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001715
NM_001286839
NM_005766

NM_134082

RefSeq (protein)

NP_001001715
NP_001273768
NP_005757

NP_598843.3
NP_598843

Location (UCSC) Chr 13: 98.14 – 98.46 Mb Chr 14: 121.04 – 121.28 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.[4][5]

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[5]

References[edit]

  1. ^ "Diseases that are genetically associated with FARP1 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y (Jan 1998). "Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors". Biochem Biophys Res Commun. 241 (2): 369–75. doi:10.1006/bbrc.1997.7826. PMID 9425278. 
  5. ^ a b "Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)". 

Further reading[edit]

External links[edit]